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Publications
7367 publication(s) trouvée(s)
Article scientifique
Current Status of Next-Generation Sequencing Approaches for Candidate Gene Discovery in Familial Parkinson´s Disease
Parkinson’s disease is a neurodegenerative disorder with a heterogeneous genetic etiology. The advent of next-generation sequencing (NGS) technologies has aided …
Article scientifique
Accessing sub-national cholera epidemiological data for Nigeria and the Democratic Republic of Congo during the seventh pandemic
BACKGROUND: Vibrio cholerae is a water-borne pathogen with a global burden estimate at 1.4 to 4.0 million annual cases. Over …
Article scientifique
Metabolite profile of African horned cucumber (Cucumis metuliferus E. May. Ex Naudin) fruit grown under differing environmental conditions
Abstract Plant metabolites are known as biological compounds that are essential to the growth and development of a plant and …
Article scientifique
Expression of whole blood miR-126-3p, -30a-5p, -1299, -182-5p and -30e-3p in chronic kidney disease in a South African community-based sample
The burden of chronic kidney disease (CKD) in Africa remains poorly characterized, due partly to the lack of appropriate diagnostic …
Article scientifique
Substantial Intestinal Microbiota Differences Between Patients With Ulcerative Colitis From Ghana and Denmark
Background Ulcerative colitis (UC) is a relapsing nontransmural inflammatory disease that is restricted to the colon and is characterized by …
Article scientifique
Heterogeneous clinical features in Cockayne syndrome patients and siblings carrying the same CSA mutations
BACKGROUND: Cockayne syndrome (CS) is a rare autosomal recessive disorder caused by mutations in ERCC6/CSB or ERCC8/CSA that participate in …
Article scientifique
Toward a Knowledge-Based System for African Traditional Herbal Medicine: A Design Science Research Approach
This article illustrates a design approach for capturing, storing, indexing, and search of African traditional herbal medicine (ATHMed) framed on …
Article scientifique
Structure and biosynthesis of carotenoids produced by a novel Planococcus sp. isolated from South Africa
Abstract Background The genus Planococcus is comprised of halophilic bacteria generally reported for the production of carotenoid pigments and biosurfactants. …
Article scientifique
Identifying transferable lessons from cholera epidemic responses by Médecins Sans Frontières in Mozambique, Malawi and the Democratic Republic of Congo, 2015–2018: a scoping review
BACKGROUND: Cholera epidemics occur frequently in low-income countries affected by concurrent humanitarian crises. Evaluations of these epidemic response remains largely …
Article scientifique
Ready-to-Eat Food as Sources of Extended-Spectrum β-Lactamase-Producing Salmonella and E. coli in Tamale, Ghana
The existence of antimicrobial-resistant pathogens in ready-to-eat food is an emerging public health concern. We evaluated the presence of extended-spectrum …
Article scientifique
Virulence determinant and antimicrobial resistance traits of Emerging MDR Shiga toxigenic E. coli in diarrheic dogs
Abstract Shiga-toxigenic Escherichiacoli (STEC) is incriminated in severe hemorrhagic enteritis in dogs, which is considered a veterinary and public health …
Article scientifique
TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming phase 1 (safety, tolerability, pharmacokinetics and pharmacodynamics in healthy Kenyan adults)
Background: Snakebites affect over 5 million people each year, and over 100,000 per year die as a result. The only …
Article scientifique
Prevalence and risk factors associated with rural women’s protected against tetanus in East Africa: Evidence from demographic and health surveys of ten East African countries
BACKGROUND: Tetanus is a deadly bacterial infection caused by Clostridium tetani wound contamination characterized muscular spasms and autonomic nervous system …
Article scientifique
Functional Differentiation of BMP7 Genes in Zebrafish: bmp7a for Dorsal-Ventral Pattern and bmp7b for Melanin Synthesis and Eye Development
Bone morphogenetic protein 7 (BMP7) belongs to the transforming growth factor β (TGF-β) family, which not only induces cartilage and …
Article scientifique
Transcriptomic analysis of methyl jasmonate treatment reveals gene networks involved in drought tolerance in pearl millet
Water deficit stress at the early stage of development is one of the main factors limiting pearl millet production. One …
Article scientifique
Prevalence and drug resistance patterns of Gram-negative enteric bacterial pathogens from diarrheic patients in Ethiopia: A systematic review and meta-analysis
BACKGROUND: Diarrhoea is the leading cause of morbidity and mortality in the world particularly in developing countries and among vulnerable …
Article scientifique
Antimicrobial resistance including Extended Spectrum Beta Lactamases (ESBL) among E. coli isolated from kenyan children at hospital discharge
BACKGROUND: Children who have been discharged from hospital in sub-Saharan Africa remain at substantial risk of mortality in the post-discharge …
Article scientifique
Methotrexate-Lactoferrin Targeted Exemestane Cubosomes for Synergistic Breast Cancer Therapy
While the treatment regimen of certain types of breast cancer involves a combination of hormonal therapy and chemotherapy, the outcomes …
Article scientifique
High prevalence of fecal carriage of Extended-spectrum beta-lactamase and carbapenemase-producing Enterobacteriaceae among food handlers at the University of Gondar, Northwest Ethiopia
BACKGROUND: Fecal carriage of extended-spectrum beta-lactamase and Carbapenemase-producing Enterobacteriaceae is a potential risk for the transmission of infection with resistant …
Article scientifique
Environmental surveillance of ESBL and carbapenemase-producing gram-negative bacteria in a Ghanaian Tertiary Hospital
Abstract Background The burden of antibiotic resistant infection is mainly felt in low-to-middle income countries, where the rate of antimicrobial …