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Biologie synthétique
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Publications
7382 publication(s) trouvée(s)
Article scientifique
Community based countrywide analysis of lactase persistence related genetic variants and their correlation with digestive symptoms in Libya
Lactose intolerance is a complex symptomatic response to lactose maldigestion that is influenced by, but not strictly determined by, the …
Article scientifique
Disorder-Induced Localization in Spliceosomal Conformational Networks for Resolving Plasmodium RNA–Driven Structural Perturbations and Predicting Functional Arrest
Article scientifique
Numerical Reliability of Logistic Gene Regulatory Network Models: Preventing Expression Shutdown and Robust Integration of Boolean-Derived ODE Systems
Gene regulatory networks are routinely translated from Boolean update rules into large continuous ODE systems integrated numerically for attractor identification, …
Article scientifique
Systems-Level Design of a Multi-Epitope Immunotherapeutic Vaccine Targeting EBV-Associated Oncogenesis
Article scientifique
Plasma small-extracellular vesicles’ proteomic signature in neoadjuvant chemotherapy–naïve breast cancer patients
Breast cancer remains a leading cause of cancer-related mortality worldwide, with obesity markedly increasing the risk in affected individuals. Liquid …
Article scientifique
NeoMiriX: An Integrated Bioinformatics Platform for Cancer Prediction Using microRNA Expression
Article scientifique
Molecular docking of polyphenols and screening of antioxidant and anticancer activity of Artemisia monosperma leaf extracts in human cancer cells
Abstract This study evaluated the polyphenol content of leaf extracts from Artemisia monosperma (AM) and investigated their antioxidant properties, cytotoxic …
Article scientifique
Nisin and rutin as potential coating agents for iron oxide nanoparticles for enhanced theranostic applications against cancer
Iron oxide nanoparticles (IONPs) have proven to be of therapeutic potential against cancer. The feature of the surface coating can …
Article scientifique
Uganda’s cholera elimination journey in a cholera endemic region of Africa
Uganda has been endemic for cholera since 1971. To reduce the threat of cholera, Uganda reviewed its approach to cholera, …
Article scientifique
Introgression of QTL hotspot regions enhances grain yield and maize lethal necrosis resistance in elite maize lines
Abstract Maize lethal necrosis (MLN) poses a severe threat to maize production in eastern and southern Africa, causing significant yield …
Article scientifique
Valorization of fruit pomaces for glycosidic enzymes production via solid state fermentation
Agro-industrial fruit pomaces represent complex, nutrient-rich substrates that can support microbial enzymes production within circular bioeconomy frameworks. This study systematically …
Article scientifique
XBNet and text mining-based genetic diseases classification
Article scientifique
Cholera in Africa: Current trends, challenges, and control towards elimination strategies
Cholera remains a substantial public health challenge in Africa, despite the availability of effective vaccines, treatment, and preventive measures. Systemic …
Article scientifique
A Novel Circulating microRNA Signature Panel as a Prognostic Biomarker for in Patients with Colorectal Cancer
BACKGROUND: Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, necessitating the development of reliable prognostic biomarkers. Circulating …
Article scientifique
Oridonin attenuates diclofenac-induced organ damage by suppressing endoplasmic reticulum stress and inflammasome activation
Background: Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) extensively prescribed in clinical practice; its use can be associated with toxic …
Article scientifique
A novel factorial design implemented spectrofluorimetric determination of caffeic acid: individual and combined assays with curcumin
Abstract In this research, we developed, for the first time, sensitive, selective, and reliable spectrofluorimetric methods for the quantitative analysis …
Article scientifique
Practical guidelines for producing non-replicating canine adenovirus vectors
Adenovirus vectors have been used for vaccine development, gene therapy, among others, because of their ease of genetic manipulation and …
Article scientifique
In vitro and in vivo antitumor activity of Laz-expressing Salmonella Typhimurium YB1 via optimized secretion and regulation
Salmonella enterica serovar Typhimurium strain YB1 is a genetically engineered obligate anaerobe with strong tumor-targeting potential. In this study, we …
Article scientifique
Biosecurity responses to fall armyworm (Spodoptera frugiperda) in Ghana and Australia: Comparative analysis and practical implications
Fall armyworm (FAW), Spodoptera frugiperda , is a highly invasive pest that threatens crop production and rural livelihoods, particularly in …
Article scientifique
Disease-specific alterations in the expression of circulating extracellular vesicle surface proteins in sepsis, hypertension and hypertensive sepsis
The diagnostic approach for sepsis is complicated by its pathophysiological heterogeneity and the absence of a gold-standard test. Moreover, the …