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Publications
7380 publication(s) trouvée(s)
Article scientifique
Population HLA coverage of experimentally characterized P. falciparum CD8+ T cell epitopes as potential components of a multi-epitope malaria vaccine construct: an in silico insight
Objective Malaria remains a significant global health challenge, with Plasmodium falciparum causing the most severe cases and deaths, particularly in …
Article scientifique
Curcumin delivery system based on biodegradable polyhydroxybuterate Chitosan copolymer and Cobalt oxide nanoparticles against colorectal cancer
In this study, a biodegradable nanocomposite composed of polyhydroxybutyrate-co-chitosan and cobalt oxide (PHB-co-CS/Co3O4) was developed for targeted and sustained in-vitro …
Article scientifique
Molecular Mechanisms of FAT Atypical Cadherin 1 (FAT1), the Hippo Pathway, and the Yes-Associated Protein (YAP) Signaling Pathways in Some Cancers
Introuduction: FAT atypical cadherin 1 (FAT1), the Hippo pathway and Yes-associated protein (YAP) signaling play significant roles in cell proliferation, …
Article scientifique
Early-life immunological and microbial differences between East African and North European children
BACKGROUND: The urbanization of African populations adopting Westernized lifestyles might be connected to changes in microbial exposure and immune system …
Article scientifique
Cytokine profiles, genetic polymorphisms, and systemic inflammatory markers in type 1 diabetes patients with COVID-19: IL-18 a predictor of disease severity
Background: Patients with Type 1 Diabetes Mellitus (T1DM) are at increased risk for severe COVID-19 due to chronic inflammation, immune …
Article scientifique
Cytotoxic activity of marine derived bioactive compounds from red sea sponges supported by LC-MS/MS profiling and molecular docking
Marine sponges are prolific sources of structurally diverse secondary metabolites with notable pharmacological potential. This study aimed to explore and …
Article scientifique
PI3K/Akt/mTOR pathway expression profiling reveals age- and subtype-specific molecular heterogeneity in the Nigerian breast cancer landscape
Introduction: Breast cancer (BC) is a molecularly heterogeneous disease, and treatment outcomes are strongly shaped by subtype-specific signalling dependencies. However, …
Article scientifique
Haloalkaliphilic archaea-mediated green synthesis of superparamagnetic Fe₃O₄ nanoparticles for electrochemical detection of ibuprofen in saline environments
Abstract The presence of pharmaceutical residues in aquatic systems poses a growing environmental concern, necessitating the development of sustainable and …
Article scientifique
Deciphering the groove-binding mode of dolutegravir with salmon sperm DNA through spectroscopic and molecular modelling approaches
Abstract Understanding how small molecules interact with DNA opens new avenues for designing smarter, more selective therapies. These studies not …
Article scientifique
Discovery of potent bisindole-based pyrazolopyridine derivatives as topoisomerase inhibitors: DNA damage induction and synergistic antileukemic activity
Introduction The development of novel anticancer agents targeting DNA replication and repair mechanisms remains a priority in leukemia therapy. In …
Article scientifique
Design, synthesis, molecular docking and cytotoxic evaluation of novel pyrimidine-based sulfonamide derivatives as potent anticancer agents: SAR insights and biological profiling
The low selectivity and significant toxicity of current chemotherapeutic medicines make the research and development of novel anticancer agents an …
Article scientifique
Transcriptional signatures of salinity tolerance in Egyptian wheat: unveiling WRKY-mediated defense mechanisms
BACKGROUND: Salinity stress severely constrains wheat productivity by impairing growth, photosynthetic efficiency, and cellular redox homeostasis. Understanding the physiological and …
Article scientifique
Genomic characterisation and antimicrobial resistance of Klebsiella species isolated from small stock and environmental sources in South Africa
Klebsiella species pose a significant public health concern due to their association with various infections and the rising levels of …
Article scientifique
Elucidating the mechanism of cefpodoxime-BSA interaction via a combination of multi-spectroscopic methods and molecular docking simulations
Abstract This research provides a comprehensive elucidation of the molecular interaction between cefpodoxime (CFP) and bovine serum albumin (BSA) through …
Article scientifique
Genetic aetiology of global developmental delay and intellectual disability in Africa: a scoping review
Background: The genetic aetiology of global developmental delay (GDD) and intellectual disability (ID) in Africa is poorly understood. This review …
Article scientifique
High-Throughput PCR Amplification of MLST Loci Using a One-Pot Approach v1
This protocol outlines a high-throughput, one-pot PCR workflow for multilocus sequence typing (MLST) in a 96-well format. It combines simplified …
Article scientifique
Grapevine hairy root culture establishment, confirmation and maintenance protocol. v1
A detailed protocol for establishing grapevine hairy root cultures via Rhizobium rhizogenes-mediated transformation of in vitro plantlets, adaptable to other …
Article scientifique
Small Language Models for Drug-Drug Interaction Extraction from Biomedical Text: A Systematic Literature Review
Drug–drug interaction (DDI) extraction from biomedical text is central to pharmacovigilance but remains challenging in resource-constrained clinical environments. While large …
Article scientifique
High ant (Hymenoptera: Formicidae) diversity revealed in Akagera National Park in eastern Rwanda
Ants represent a crucial component of terrestrial ecosystems owing to their roles in nutrient cycling, soil aeration and predation. However, …
Article scientifique
Master Protocol: A 60-Minute Universal Green-Chemistry Workflow for RNA Extraction and Integrity Analysis v1
This protocol is validated for Gram-Positive (GP) bacteria, Gram-Negative (GN) bacteria, and Yeast/Fungi.