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Publications
7365 publication(s) trouvée(s)
Article scientifique
Diagnostic, prognostic, and therapeutic potentials of gut microbiome profiling in human schistosomiasis: A comprehensive systematic review
BACKGROUND: Several studies have highlighted alteration in the gut microbiome associated with the onset and progression of diseases. Recognizing the …
Article scientifique
Genomic epidemiology of enteropathogenic Escherichia coli (EPEC) in southwestern Nigeria
Abstract Background Enteropathogenic Escherichia coli (EPEC) are etiological agents of diarrhea. We studied the genetic diversity and virulence factors of …
Article scientifique
Occurrence and characterization of fungal species in medicinal plants from South Africa
Abstract Fungal contamination of medicinal plants poses significant health risks due to the potential production of mycotoxins. In South Africa …
Article scientifique
Metabolic consequences and nailfold capillary changes in children with familial Mediterranean fever
BACKGROUND: There's an increasing role of nailfold capillaroscopy in the evaluation of peripheral vascular disease in chronic inflammatory disorders. Familial …
Article scientifique
Bacteraemia in a Nigerian hospital: Implementing antimicrobial resistance surveillance
Background: Surveillance of drug-resistant infections is crucial for antimicrobial resistance (AMR) control. Implementing surveillance in low- and middle-income countries (LMICs) …
Article scientifique
Evaluation of primary health care nurses’ knowledge and neonatal screening performance for phenylketonuria in Alexandria
INTRODUCTION: Nurses play a crucial role in the primary prevention of phenylketonuria (PKU) within national screening programs for newborns. This …
Article scientifique
Navigating water crisis, cholera, and refugee context: Lessons from Nakivale refugee settlement, Isingiro District, Uganda
Inadequate safe water supply and cholera outbreaks are significant contributors to ill health in displaced populations, exacerbating the vulnerability of …
Article scientifique
Cyclic di AMP phosphodiesterase nanovaccine elicits protective immunity against Burkholderia cenocepacia infection in mice
Burkholderia cenocepacia causes life-threatening infections in immunocompromised patients. Treatment is challenging due to intrinsic antibiotic multiresistance, so vaccination provides an …
Article scientifique
Enterococcus and Eggerthella species are enriched in the gut microbiomes of COVID-19 cases in Uganda
BACKGROUND: Infection with the COVID-19-causing pathogen SARS-CoV-2 is associated with disruption in the human gut microbiome. The gut microbiome enables …
Article scientifique
Novel 5,6-dichlorobenzimidazole derivatives as dual BRAFWT and BRAFV600E inhibitors: design, synthesis, anti-cancer activity and molecular dynamics simulations
Abstract A new series of 1-substiuted-5,6-dichloro-2-(4-methoxyphenyl)-1H-benzo[d]imidazoles 10a–p was designed and synthesized to target both BRAFWT and BRAFV600E. The design strategy …
Article scientifique
The bilateral cross communication in microbiota-gut-brain axis as a promising therapeutic target for Alzheimer’s disease: a focus on neuroinflammation
Abstract The microbiota- gut-brain interaction is a fundamental aspect of the synergy between microbiota and host in accessing gut-brain signaling …
Article scientifique
Optimization of citrulline production from a Bacillus subtilis BH-01 isolated from raw buffalo milk
The main purpose of this study was to optimize the L-citrulline production process using Plackett-Burman and Box-Behnken designs. L-citrulline-producing bacterium …
Article scientifique
Long-read 16S rRNA amplicon sequencing reveals microbial characteristics in patients with colorectal adenomas and carcinoma lesions in Egypt
BACKGROUND: Colorectal cancer (CRC) is among the five leading causes of cancer incidence and mortality. During the past decade, the …
Article scientifique
Risk factors for Carbapenem-resistant Enterobacterales infections: A case-control study
BACKGROUND: Over years, concerning Carbapenem-resistant Enterobacterales (CRE) have advanced globally, posing a major threat to global health. Prior studies highlight …
Article scientifique
Naringenin-loaded nanoparticles modulate HIF-driven oxygen-sensing pathways in lung adenocarcinoma cells
BACKGROUND: Hypoxia is a common symptom of lung cancer. Proliferation and neovascularization mediated by hypoxia-inducible factors (HIF) influence several adaptations. …
Article scientifique
Design and assessment of lipase-CuO nanoparticle conjugates for enhanced antimicrobial efficacy against clinical pathogens
In the battle against clinical infections particularly the resistant pathogens, the creation of new antimicrobial drugs is essential. This study …
Article scientifique
Detection of AdeAB, TetA, and TetB efflux pump genes in clinical isolates of tetracycline-resistant Acinetobacter baumannii from patients of Suez Canal University Hospitals
BACKGROUND: Acinetobacter baumannii is an opportunistic bacteria associated primarily with hospital-acquired infections. Its tendency to acquire or donate resistance genes …
Article scientifique
L-glutaminase synthesis by Klebsiella pneumoniae (AS KP 23) isolated from clinical strain, and its efficacy against human hepatocellular and breast cancer cell lines
BACKGROUND: Cancer is a major cause of morbidity and mortality worldwide. The proliferation of cancer cells depends largely on glutamine …
Article scientifique
Expression Analysis of Oxidative Stress Markers 8-hydroxydeoxyguanosine and Protein Carbonyl in Breast Cancer and Their associations with Certain Immunological and Tumor Markers
OBJECTIVE: Breast cancer (BC) is a heterogeneous disease, recognized as a major public health problem worldwide, with several risk factors …
Article scientifique
Knowledge, attitudes, and self-reported practices regarding cholera among six MENA countries following cholera outbreaks in the region
BACKGROUND: Cholera persists as a global public health threat, endangering the lives of vulnerable societies including the MENA region where …