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H3Africa AWI-Gen Collaborative Centre: a resource to study the interplay between genomic and environmental risk factors for cardiometabolic diseases in four sub-Saharan African countries

Article scientifique 2016 Anglais

Résumé

Africa is experiencing a rapid increase in adult obesity and associated cardiometabolic diseases (CMDs). The H3Africa AWI-Gen Collaborative Centre was established to examine genomic and environmental factors that influence body composition, body fat distribution and CMD risk, with the aim to provide insights towards effective treatment and intervention strategies. It provides a research platform of over 10 500 participants, 40-60 years old, from Burkina Faso, Ghana, Kenya and South Africa. Following a process that involved community engagement, training of project staff and participant informed consent, participants were administered detailed questionnaires, anthropometric measurements were taken and biospecimens collected. This generated a wealth of demographic, health history, environmental, behavioural and biomarker data. The H3Africa SNP array will be used for genome-wide association studies. AWI-Gen is building capacity to perform large epidemiological, genomic and epigenomic studies across several African counties and strives to become a valuable resource for research collaborations in Africa.

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Ramsay, M., Crowther, N., Tambo, E., Agongo, G., Baloyi, V., Dikotope, S., Gómez‐Olivé, F., Jaff, N., Sorgho, H., Wagner, R., Khayeka‐Wandabwa, C., Choudhury, A., Hazelhurst, S., Kahn, K., Lombard, Z., Mukomana, F., Soo, C., Soodyall, H., Wade, A., Afolabi, S., Agorinya, I., Amenga–Etego, L., Ali, S., Bognini, J., Boua, P., Debpuur, C., Fato, E., Kazienga, A., Konkobo, S., Kouraogo, P., Mashinya, F., Micklesfield, L., Nakanabo‐Diallo, S., Njamwea, B., Nonterah, E., Ouédraogo, S., Pillay, V., Somande, A., Tindana, P., Twine, R., Alberts, M., Kyobutungi, C., Norris, S., Oduro, A., Tinto, H., Tollman, S., Sankoh, O. (2016). H3Africa AWI-Gen Collaborative Centre: a resource to study the interplay between genomic and environmental risk factors for cardiometabolic diseases in four sub-Saharan African countries. https://doi.org/10.1017/gheg.2016.17

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Auteur(s)

Michèle Ramsay Nigel J. Crowther Ernest Tambo Godfred Agongo Vukosi Baloyi S.A. Dikotope F. Xavier Gómez‐Olivé Nicole G. Jaff Hermann Sorgho Ryan G. Wagner Christopher Khayeka‐Wandabwa Ananyo Choudhury Scott Hazelhurst Kathleen Kahn Zané Lombard Freedom Mukomana Cassandra Claire Soo Himla Soodyall Alisha N. Wade Sulaimon Afolabi Isaiah Agorinya Lucas Amenga–Etego Stuart A. Ali Joel D. Bognini Palwendé Romuald Boua Cornelius Debpuur E. Fato Adama Kazienga Sophie Z. Konkobo Patrice Kouraogo Felistas Mashinya Lisa K. Micklesfield Seydou Nakanabo‐Diallo Brian Njamwea Engelbert A. Nonterah Samiratou Ouédraogo Venesa Pillay A. M. Somande Paulina Tindana Rhian Twine Marianne Alberts Catherine Kyobutungi Shane A. Norris Abraham Oduro Halidou Tinto Stephen Tollman Osman Sankoh

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