Impact of N6-methyladenosine (m6A) modification on immunity

Abstract N6-methyl-adenosine (m 6 A) is the most prevalent modification on mRNAs and long noncoding RNAs (lnRNAs) in higher eukaryotes. Modulation of m 6 A relies on m 6 A writers, erasers and readers. m 6 A modification contributes to diverse fundamental biological functions at the molecular, cellular, and physiological levels. The dysregulation of m 6 A modification has been implicated in various human diseases. Thus, m 6 A modification has now become a research hotspot for its potential therapeutic applications in the treatment of various cancers and diseases. The immune system is essential to provide defense against infections and cancers. This review summarizes the current knowledge about the roles of m 6 A in regulating immune cell functions and immune responses.