440 publication(s) trouvée(s)
Article scientifique
Diagnostic and Prognostic Values of Microfibrillar-Associated Protein 5 and Heat Shock Protein 90 Alpha in Patients with HCV-Induced Hepatocellular Carcinoma Undergoing Locoregional Therapy
OBJECTIVES: This study aimed to assess the role of HSP90 alpha and MFAP5 as potential diagnostic and prognostic markers for …
Article scientifique
Intersecting Burdens: HIV Prevalence and Cervical Cancer Progression Among Women in the Eastern Cape, South Africa: A Retrospective Descriptive Study
BACKGROUND: Cervical cancer remains a leading cause of cancer-related mortality in low- and middle-income countries, especially in sub-Saharan Africa, where …
Article scientifique
Mapping the Prevalence of BRCA1 and BRCA2 Mutations in Hereditary Breast and Ovarian Cancer Across Africa: A Systematic Review and Meta-Analysis
BACKGROUND: BRCA1 and BRCA2 gene mutations are major contributors to hereditary breast and ovarian cancer syndrome (HBOC). While mutation prevalence …
Article scientifique
Influence of Exosomes on Tumorigenic Behavior in Triple-Negative Breast Cancer Cells through STAT3 Inhibition in Autophagy
OBJECTIVES: The prime aim of this research was to evaluate the effect of exosomes on the tumorigenic behavior of TNBC …
Article scientifique
Cancer Distribution Pattern in the City of Kenitra, Morocco (2017-2022): A Pathology-Based Study
BACKGROUND: Cancer epidemiological surveillance is essential for implementing an effective prevention policy. In Morocco, only two population-based cancer registries (Rabat …
Article scientifique
Development and Validation of a One-Step Multiplex RT-qPCR Assay for BCR-ABL1 Transcript Detection and Monitoring in Moroccan Chronic Myeloid Leukemia Patients
OBJECTIVE: Chronic myeloid leukemia (CML) is driven by the BCR-ABL1 fusion gene. Molecular monitoring of this transcript is essential for …
Article scientifique
Superiority of Adjuvant Hyperfractionated Radiotherapy Over Chemotherapy Following Radical Cystectomy
BACKGROUND: Bladder cancer (LABC) after radical cystectomy (RC) is common, even with chemotherapy, and is associated with high morbidity and …
Article scientifique
Study of the Role of Circulating Cell-Free DNA in the Diagnosis of Cholangiocarcinoma
BACKGROUND: Cholangiocarcinoma (CCA) is an aggressive biliary malignancy usually diagnosed at advanced stages because early symptoms are vague. Conventional serum …
Article scientifique
Expression and Prognostic Value of Serum microRNA- 375 and microRNA- 182 in Correlation with Tissue Immunehistochemical Expression of Related Proteins, Serving as Novel Biomarkers in Colorectal Cancer
BACKGROUND: Colorectal cancer (CRC) commonly evolves through precursor adenomatous polyps; however, reliable non-invasive biomarkers capable of distinguishing benign from malignant …
Article scientifique
HCC-miR: A Simple, Noninvasive, and Sensitive Model for Early Diagnosis of HCV-Associated Hepatocellular Carcinoma
BACKGROUND: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and a major cause of cancer-related mortality worldwide. Chronic …
Article scientifique
Melatonin Receptors in Uterine Leiomyomas: An Immunohistochemical Study
BACKGROUND: Uterine leiomyomas are the most common benign tumors in women of reproductive age, often causing significant symptoms such as …
Article scientifique
Vitamin D3 Supplementation Modulates C-MYC/VEGF and Improves Chemotherapy Outcomes in Metastatic CRC Patients: Integrated Clinical–Mechanistic Evidence
OBJECTIVE: Systemic chemotherapy with fluoropyrimidine regimens is the cornerstone of management for unresectable metastatic colorectal cancer (CRC). This study aimed …
Article scientifique
Gene Expression Alterations of TIMP3, ELASTIN, K-RAS, and BRAF in Colorectal Cancer Patients with H. pylori Infection
OBJECTIVE: Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related mortality worldwide, with …
Article scientifique
The Prognostic and Predictive Value of METTL3 in Metastatic Colorectal Cancer
BACKGROUND: Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide, and its incidence continues to rise. The prognosis …
Article scientifique
Optimizing Care Trajectories with Artificial Intelligence: A Systematic Review and Meta-Analysis
OBJECTIVE: This study aims to provide a critical and comprehensive summary of existing research on the effectiveness of AI-assisted care …
Article scientifique
In Vitro Anticancer Activity of Green-Synthesized Zinc Oxide Nanoparticles from Root Extract of Sida schimperiana against MDA-MB-231 Breast Cancer Cell Lines
OBJECTIVE: This work addressed the fact that nano phytoformulations have emerged as promising, biocompatible alternatives to conventional cancer drugs, helping …
Article scientifique
Knowledge, Attitudes, and Practices Regarding Colorectal Cancer Screening Among Medical Residents: An Exploratory, Single-Center, Cross-Sectional Study from Egypt
OBJECTIVE: Colorectal cancer (CRC) in Egypt has a high incidence of early-onset cases compared to Western countries. However, screening rates …
Article scientifique
A Novel Circulating microRNA Signature Panel as a Prognostic Biomarker for in Patients with Colorectal Cancer
BACKGROUND: Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, necessitating the development of reliable prognostic biomarkers. Circulating …
Article scientifique
The Prognostic Impact of Supraclavicular Lymph Node Metastases in Lung Cancer: Do We Need a Modification of the Current Staging System?
BACKGROUND: The management of Stage IIIB non-small-cell lung cancer (NSCLC) is complex. The current staging system does not distinguish between …
Article scientifique
Prediction of Outcomes of Brain Irradiation in Correlation with Molecular Subtypes in Patients with Metastatic Breast Cancer
BACKGROUND: Brain metastases (BM) are a major complication in metastatic breast cancer, especially in HER2-positive and triple-negative subtypes. Despite advances …
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