1373 publication(s) trouvée(s)
Article scientifique
Evaluating performance of the Bioline™ HCV point-of-care test in Ghana
BACKGROUND: Hepatitis C Virus (HCV) causes liver diseases including chronic hepatitis, cirrhosis, and hepatocellular carcinoma. In low- and middle-income countries …
Article scientifique
Gaps in HIV testing among people with presumptive TB in Mozambique: a 3-year retrospective cohort study
BACKGROUND: HIV testing among people with presumptive tuberculosis (PP-TB) represents a critical entry point for HIV diagnosis and care, especially …
Article scientifique
Risk factors for Streptococcus pyogenes skin infections during an outbreak in Ethiopia: a case-control study
BACKGROUND: Despite being in existence for hundreds of years, Streptococcus pyogenes remains a significant cause of global morbidity and mortality, …
Article scientifique
Suppnonsense-mediated decay-linked mutations in SARS-CoV-2 and their association with COVID-19 disease severity
BACKGROUND: Nonsense-mediated decay (NMD) is a cellular mechanism that degrades mRNAs with premature termination codons (PTCs), preventing the production of …
Article scientifique
Pristinamycin-antibiotic combinations against methicillin-resistant Staphylococcus aureus recovered from skin infections
BACKGROUND: Macrolide-resistant and methicillin-resistant Staphylococcus aureus, particularly those exhibiting pristinamycin resistance, impose significant medical health consequences with limited therapeutic options. …
Article scientifique
Assessing SARS-CoV-2 vaccine effectiveness in health workers: a cohort study conducted during the pandemic decline phase in five hospitals, affiliated to Al-Azhar University- Egypt
OBJECTIVE: A cohort study was conducted with the support of the WHO, where a standardized WHO protocol was followed to …
Article scientifique
Repeated introductions and widespread transmission of human metapneumovirus in Côte d’Ivoire
In Cote d'Ivoire, the incidence rate of acute respiratory infections (ARIs) rose from 165 cases per 1000 children in 2014 …
Article scientifique
Impact of an antimicrobial stewardship program on optimizing linezolid consumption and susceptibility in intensive care unit patients with methicillin-resistance staphylococcus aureus: a retrospective cohort study
BACKGROUND: The empirical use of linezolid as a first-line agent for Methicillin-Resistant Staphylococcus Aureus (MRSA) without a clear indication is …
Article scientifique
Coexistence of carbapenem resistance and hypervirulence in clinical Klebsiella pneumoniae isolates: a molecular and phenotypic analysis
Abstract Background Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CRhvKp) is increasingly recognized as the predominant nosocomial pathogen in healthcare environments. Objective This …
Article scientifique
Nasopharyngeal carriage and risk factors of major meningitis pathogens among asymptomatic healthcare workers in paediatric units in Benin, with serogroup distribution of Neisseria meningitidis
BACKGROUND: Healthcare workers in paediatric settings are in close contact with vulnerable children and may serve as reservoirs and vectors …
Article scientifique
Targeting invasion-associated proteins PfSUB2 and PfTRAMP in Plasmodium falciparum: identification of potential inhibitors via molecular docking
Plasmodium falciparum subtilisin-like protease 2 (PfSUB2) is responsible for processing Plasmodium falciparum thrombospondin-related apical merozoite protein (PfTRAMP). These proteins are …
Article scientifique
Diabetes and metabolic syndrome in adults with malaria and associations with severe disease: results from two tertiary hospitals in Cameroon
BACKGROUND: The prevalence of lifestyle-associated diseases is increasing in sub-Saharan Africa. This study investigated the prevalence of metabolic co-morbidities in …
Article scientifique
Understanding barriers and facilitators to doxycycline post-exposure prophylaxis adherence among young women in western kenya: a qualitative study
Sexually transmitted infection (STI) rates are high globally, particularly in regions like sub-Saharan Africa, where there is also a disproportionate …
Article scientifique
Investigation of chronic limb ulcers in Northern Cameroon: a socio-anthropological and clinical perspective
BACKGROUND: In September 2023, fifty cases of chronic limb ulcers of unknown origin were reported in six Health Districts (HDs) …
Article scientifique
Prior antiretroviral therapy exposure among clients presenting for HIV treatment initiation in South Africa: an exploratory mixed-methods study using multiple indicators of exposure
BACKGROUND: The era of universal treatment for HIV has seen high rates of disengagement from antiretroviral therapy (ART) programs and …
Article scientifique
Forecasting tuberculosis in Ethiopia using deep learning: progress toward sustainable development goal evidence from global burden of disease 1990–2021
BACKGROUND: Tuberculosis (TB) is a preventable and treatable disease caused by Mycobacterium tuberculosis, which most often affects lungs and remains …
Article scientifique
Emerging antibiotic resistance in Vibrio cholerae: a study of cholera prevalence and resistance patterns in Zambia’s Copperbelt Province
INTRODUCTION: Cholera remains a significant public health challenge in Zambia, particularly in the Copperbelt Province, where antibiotic-resistant Vibrio cholerae strains …
Article scientifique
Post-treatment time to symptom resolution and associated factors in a cohort of Ugandan men with urethral discharge syndrome
INTRODUCTION: Ugandan men with urethral discharge syndrome (UDS) have high burdens of curable sexually transmitted infections (STIs) and HIV. STI …
Article scientifique
Time series modelling and forecasting of mpox incidence and mortality in Nigeria
The World Health Organization (WHO) declared mpox a Public Health Emergency of International Concern (PHEIC) twice, in response to the …
Article scientifique
Comparative genomics of Acinetobacter baumannii from Egyptian healthcare settings reveals high-risk clones and resistance gene mobilization
Abstract Background Acinetobacter baumannii (A. baumannii) has emerged as a major public health threat in low- and middle-income countries (LMICs), …