11 publication(s) trouvée(s)
Article scientifique
Hemifusomes and proteolipid nanodroplets: a critical synthesis of an emerging model for endosomal membrane remodeling
Vesicular membrane trafficking is central to eukaryotic homeostasis, governing receptor downregulation, lysosomal degradation, and intercellular communication via exosomes. These processes …
Article scientifique
SARS-CoV-2-associated lymphopenia: possible mechanisms and the role of CD147
T lymphocytes play a primary role in the adaptive antiviral immunity. Both lymphocytosis and lymphopenia were found to be associated …
Article scientifique
Targeting Wnt/β-catenin signaling and its interplay with TGF-β and Notch signaling pathways for the treatment of chronic wounds
Wound healing is a tightly regulated process that ensures tissue repair and normal function following injury. It is modulated by …
Article scientifique
New trends in cell death: overview of the International Society of Cell Death (ICDS) annual meeting in Johannesburg South Africa (May 19-22, 2023)
Article scientifique
Deciphering the dynamics of methicillin-resistant Staphylococcus aureus biofilm formation: from molecular signaling to nanotherapeutic advances
Methicillin-resistant Staphylococcus aureus (MRSA) represents a global threat, necessitating the development of effective solutions to combat this emerging superbug. In …
Article scientifique
It is the time for quorum sensing inhibition as alternative strategy of antimicrobial therapy
Multiple drug resistance poses a significant threat to public health worldwide, with a substantial increase in morbidity and mortality rates. …
Article scientifique
Impact of N6-methyladenosine (m6A) modification on immunity
Abstract N6-methyl-adenosine (m 6 A) is the most prevalent modification on mRNAs and long noncoding RNAs (lnRNAs) in higher eukaryotes. …
Article scientifique
ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells
BACKGROUND: HER3/ErbB3 receptor deletion or blockade leads to tumor cell apoptosis, whereas its overexpression confers anti-cancer drug resistance through upregulation …
Article scientifique
Cholesterol content in cell membrane maintains surface levels of ErbB2 and confers a therapeutic vulnerability in ErbB2-positive breast cancer
BACKGROUND: ErbB2 overexpression identifies a subset of breast cancer as ErbB2-positive and is frequently associated with poor clinical outcomes. As …
Article scientifique
The nuclear transportation routes of membrane-bound transcription factors
Membrane-bound transcription factors (MTFs) are transcription factors (TFs) that are anchored in membranes in a dormant state. Activated by external …
Article scientifique
CD146, a novel target of CD44-signaling, suppresses breast tumor cell invasion
BACKGROUND: We have previously validated three novel CD44-downstream positively regulated transcriptional targets, including Cortactin, Survivin and TGF-β2, and further characterized …