31 publication(s) trouvée(s)
Article scientifique
Antineoplastic effect of piperine compared with doxorubicin via suppressing γ-secretase/notch pathway in breast cancer cells
Breast carcinoma is the most prevalent and lethal malignancy affecting females, and it always presents an essential healthcare problem. Doxorubicin …
Article scientifique
Genetic influence of PPAR-γ rs1801282 and MTRR rs162036 variants on non-small cell lung cancer risk in Egyptians
BACKGROUND: Lung cancer remains the leading cause of cancer-related deaths worldwide. Despite advances in diagnostics and treatment, most patients are …
Article scientifique
Role of microRNA-183 based theranostics through targeting TPM1 in bladder cancer
BACKGROUND: MicroRNA-183 (miR-183-5p), a noncoding RNA, is upregulated in bladder carcinoma (BC). Although it has been implicated in oncogenesis, its …
Article scientifique
The multifaceted roles of ZIC genes in cancer: from development regulators to cancer modulators
ZIC genes, which endcode zinc finger transcription factors, are recognized for their foundational roles in vertebrate development and have been …
Article scientifique
The involvement of exosomes in the tumorigenicity of breast cancer cell lines through the crosstalk between STAT3, Notch, and Wnt signaling pathways
BACKGROUND: Exosomes play a critical role in the tumor microenvironment by interacting with signaling pathways that facilitate breast cancer metastasis, …
Article scientifique
Diagnosis and treatment outcomes of primary lymphoma of the thyroid gland
INTRODUCTION: Primary thyroid lymphoma (PTL) is a rare extranodal malignancy accounting for less than 5% of thyroid cancer, with a …
Article scientifique
Evaluation of human papillomavirus as a risk factor in prostate cancer pathogenesis
Prostate cancer (PCa) is the most prevalent and leading cause of cancer-related deaths among men in most countries around the …
Article scientifique
Mucinous carcinoma of the breast: epidemiological, clinical, and prognostic characteristics; a single-center experience
INTRODUCTION: Mucinous (colloid) carcinoma (MC) of the breast typically affects postmenopausal and elderly women, with a more favorable prognosis compared …
Article scientifique
Impact of differential detection of TM6SF2 rs58542926 mutation in circulating tumor DNA versus peripheral blood cells on hepatocellular carcinoma patients
This study aimed to investigate the differential distribution of the genotypes of the TM6SF2 rs58542926 polymorphism in circulating tumor DNA …
Article scientifique
Adaptive immune changes in colorectal cancer: a focus on T and B cell activation genes
Abstract Colorectal cancer (CRC) ranks as the third most common cancer globally and is the second leading cause of cancer-related …
Article scientifique
Targeting inflammatory pathways in hepatocellular carcinoma: recent developments
Chronic inflammation is a well-established driver of malignancy in many various cancer conditions. Hepatocellular carcinoma (HCC) is a significant illustrator …
Article scientifique
Nanotechnology in oncology: advances in biosynthesis, drug delivery, and theranostics
Nanotechnology has revolutionized oncology by offering innovative solutions to overcome the limitations of conventional cancer therapies. This review explores the …
Article scientifique
CD155 as a prognostic and predictive biomarker in acute myeloid leukemia
BACKGROUND: Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy with different molecular and genetic alterations. CD155 is expressed on …
Article scientifique
Therapy-related second malignant neoplasms on top of neuroblastoma: frequency, types and risk factors
OBJECTIVES: The aim of the study was to evaluate the long-term effect of multi-modal, risk-based treatment protocols on the development …
Article scientifique
Modulatory effect of metformin and its transporters on immune infiltration in tumor microenvironment: a bioinformatic study with experimental validation
Metformin is a traditional antidiabetic drug for type 2 diabetes mellitus. However, it showed antitumor activity in many types of …
Article scientifique
Safranal-loaded gold nanoparticles alleviate hepatocellular carcinoma via targeting the Wnt/β-catenin pathway
BACKGROUND: The Wnt/β-catenin pathway is frequently activated in hepatocellular carcinoma (HCC); thus, it is considered a potential target for novel …
Article scientifique
The prognostic value of the central location of pulmonary nodules in osteosarcoma patients
BACKGROUND: Most metastatic osteosarcoma pulmonary nodules exist in the periphery of the lung, while other lesions are close to the …
Article scientifique
Mitochondria in cancer: a comprehensive review, bibliometric analysis, and future perspectives
INTRODUCTION: Mitochondria are essential organelles for many aspects of cellular homeostasis. They play an indispensable role in the development and …
Article scientifique
A comprehensive review on targeted therapies for triple negative breast cancer: an evidence-based treatment guideline
Triple-negative breast cancer (TNBC) is an aggressive malignancy characterized by limited therapeutic options and poor prognosis. Despite advancements in precision …
Article scientifique
The effectiveness and reliability of autologous hematopoietic stem cell transplantation following chemotherapy in managing malignant lymphoma: a meta-analysis
BACKGROUND: Autologous hematopoietic stem cell transplantation (AHSCT) is a valuable treatment option for several hematological malignancies, particularly in relapsed or …
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