40 publication(s) trouvée(s)
Article scientifique
Human genetic ancestry, Mycobacterium tuberculosis diversity, and tuberculosis disease severity in Dar es Salaam, Tanzania
Infectious diseases have affected humanity for millennia and are among the strongest selective forces. Tuberculosis (TB) is an ancient disease, …
Article scientifique
Cestode larvae excite host neuronal circuits via glutamatergic signalling
Neurocysticercosis (NCC) is caused by infection of the brain by larvae of the parasitic cestode Taenia solium . It is …
Article scientifique
Pronounced expression of extracellular matrix proteoglycans regulated by Wnt pathway underlies the parallel evolution of lip hypertrophy in East African cichlids
Cichlid fishes inhabiting the East African Great Lakes, Victoria, Malawi, and Tanganyika, are textbook examples of parallel evolution, as they …
Article scientifique
Insulin control in fruit flies
Investigating how the production of insulin is regulated in fruit flies reveals surprising insights that may help to better understand …
Article scientifique
Confirmation of HLA-II associations with TB susceptibility in admixed African samples
Previously, the International Tuberculosis Host Genetics Consortium (ITHGC) demonstrated the power of large-scale GWAS analysis across diverse ancestries in identifying …
Article scientifique
T-follicular helper cell profiles differ by malaria antigen and for children compared to adults
Circulating T-follicular helper (cT FH ) cells have the potential to provide an additional correlate of protection against Plasmodium falciparum …
Article scientifique
Monitoring livestock pregnancy loss
Systematically tracking and analysing reproductive loss in livestock helps with efforts to safeguard the health and productivity of food animals …
Article scientifique
A Novel Imaging Method (FIM-ID) Reveals that Myofibrillogenesis Plays a Major Role in the Mechanically Induced Growth of Skeletal Muscle
Abstract An increase in mechanical loading, such as that which occurs during resistance exercise, induces radial growth of muscle fibers …
Article scientifique
A transmission bottleneck for malaria? Quantification of sporozoite expelling by Anopheles mosquitoes infected with laboratory and naturally circulating P. falciparum gametocytes
Abstract It is currently unknown whether all Plasmodium falciparum infected mosquitoes are equally infectious. We assessed sporogonic development using cultured …
Article scientifique
A kinase to cytokine explorer to identify molecular regulators and potential therapeutic opportunities
Cytokines and chemokines are secreted proteins that regulate various biological processes, such as inflammation, immune response, and cell differentiation. Therefore, …
Article scientifique
Measuring changes in Plasmodium falciparum census population size in response to sequential malaria control interventions
Abstract Here we introduce a new endpoint “census population size” to evaluate the epidemiology and control of Plasmodium falciparum infections, …
Article scientifique
A Novel Imaging Method (FIM-ID) Reveals that Myofibrillogenesis Plays a Major Role in the Mechanically Induced Growth of Skeletal Muscle
Abstract An increase in mechanical loading, such as that which occurs during resistance exercise, induces radial growth of muscle fibers …
Article scientifique
Strong isolation by distance and evidence of population microstructure reflect ongoing Plasmodium falciparum transmission in Zanzibar
Abstract The Zanzibar archipelago of Tanzania has become a low-transmission area for Plasmodium falciparum. Despite being considered an area of …
Article scientifique
Hsf1 and the molecular chaperone Hsp90 support a “rewiring stress response” leading to an adaptive cell size increase in chronic stress
Abstract Cells are exposed to a wide variety of internal and external stresses. Whereas many studies have focused on cellular …
Article scientifique
A transmission bottleneck for malaria? Quantification of sporozoite expelling from laboratory and natural P. falciparum infections
Abstract It is currently unknown whether all Plasmodium falciparum infected mosquitoes are equally infectious. We assessed sporogonic development using cultured …
Article scientifique
Chromosome-specific maturation of the epigenome in the Drosophila male germline
Abstract Spermatogenesis in the Drosophila male germline proceeds through a unique transcriptional program controlled both by germline-specific transcription factors and …
Article scientifique
Basement membranes are crucial for proper olfactory placode shape, position and boundary with the brain, and for olfactory axon development
Despite recent progress, the complex roles played by the extracellular matrix in development and disease are still far from being …
Article scientifique
A robust method for measuring aminoacylation through tRNA-Seq
Abstract Current methods to quantify the fraction of aminoacylated tRNAs, also known as the tRNA charge, are limited by issues …
Article scientifique
Strong isolation by distance and evidence of population microstructure reflect ongoing Plasmodium falciparum transmission in Zanzibar
Background: The Zanzibar archipelago of Tanzania has become a low-transmission area for Plasmodium falciparum . Despite being considered an area …
Article scientifique
Evolutionary trade-offs in dormancy phenology
Seasonal animal dormancy is widely interpreted as a physiological response for surviving energetic challenges during the harshest times of the …
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