40 publication(s) trouvée(s)
Article scientifique
De novo fatty-acid synthesis protects invariant NKT cells from cell death, thereby promoting their homeostasis and pathogenic roles in airway hyperresponsiveness
Abstract Invariant natural-killer T (iNKT) cells play pathogenic roles in allergic asthma in murine models and possibly also humans. While …
Article scientifique
KinCytE- a Kinase to Cytokine Explorer to Identify Molecular Regulators and Potential Therapeutic Opportunities
Abstract Cytokines and chemokines are secreted proteins that regulate various biological processes, such as inflammation, immune response, and cell differentiation. …
Article scientifique
Stumpy forms are the predominant transmissible forms of Trypanosoma brucei
demonstrated that bloodstream slender forms of African trypanosomes are readily transmissible to young tsetse flies where they can complete their …
Article scientifique
Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation
Abstract Allergic asthma is a disease driven by T helper 2 (Th2) cells, eosinophilia, airway hyperresponsiveness (AHR) and IgE-secreting B …
Article scientifique
Broca’s area, variation and taxic diversity in early Homo from Koobi Fora (Kenya)
Abstract Because brain tissues rarely fossilize, pinpointing when and how modern human cerebral traits emerged in the hominin lineage is …
Article scientifique
Gender differences in submission behavior exacerbate publication disparities in elite journals
Abstract Women are particularly underrepresented in journals of the highest scientific impact, with substantial consequences for their careers. While a …
Article scientifique
Chromosome-specific maturation of the epigenome in the Drosophila male germline
Abstract Spermatogenesis in the Drosophila male germline proceeds through a unique transcriptional program controlled both by germline-specific transcription factors and …
Article scientifique
Differences in the inflammatory proteome of East African and Western European adults and associations with environmental and dietary factors
Non-communicable diseases (NCDs) are rising rapidly in urbanizing populations in sub-Saharan Africa. Assessment of inflammatory and metabolic characteristics of a …
Article scientifique
An initial report of circa 241,000- to 335,000-year-old rock engravings and their relation to Homo naledi in the Rising Star cave system, South Africa
The production of painted, etched, or engraved designs on cave walls or other surfaces is recognized as a major cognitive …
Article scientifique
Evidence for deliberate burial of the dead by Homo naledi
Abstract Recent excavations in the Rising Star Cave System of South Africa have revealed burials of the extinct hominin species …
Article scientifique
Association of close-range contact patterns with SARS-CoV-2: a household transmission study
Background: Households are an important location for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, especially during periods when travel …
Article scientifique
Influenza virus transcription and progeny production are poorly correlated in single cells
The ultimate success of a viral infection at the cellular level is determined by the number of progeny virions produced. …
Article scientifique
Broca’s area, variation and taxic diversity in early Homo from Koobi Fora (Kenya)
Abstract Because brain tissues rarely fossilize, pinpointing when and how modern human cerebral traits emerged in the hominin lineage is …
Article scientifique
De novo fatty-acid synthesis protects invariant NKT cells from cell death, thereby promoting their homeostasis and pathogenic roles in airway hyperresponsiveness
Abstract Invariant natural-killer T (iNKT) cells play pathogenic roles in allergic asthma in murine models and possibly also humans. While …
Article scientifique
Uremic toxin indoxyl sulfate induces trained immunity via the AhR-dependent arachidonic acid pathway in end-stage renal disease (ESRD)
Trained immunity is the long-term functional reprogramming of innate immune cells, which results in altered responses toward a secondary challenge. …
Article scientifique
Genome editing of an African elite rice variety confers resistance against endemic and emerging Xanthomonas oryzae pv. oryzae strains
Bacterial leaf blight (BB) of rice, caused by Xanthomonas oryzae pv. oryzae ( Xoo ), threatens global food security and …
Article scientifique
Boosting in the age of Omicron
A third dose of the inactivated vaccine CoronaVac fails to stimulate the production of neutralizing antibodies which target the Omicron …
Article scientifique
Statistical inference reveals the role of length, GC content, and local sequence in V(D)J nucleotide trimming
To appropriately defend against a wide array of pathogens, humans somatically generate highly diverse repertoires of B cell and T …
Article scientifique
Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction
DUX4 activates the first wave of zygotic gene expression in the early embryo. Mis-expression of DUX4 in skeletal muscle causes …
Article scientifique
Ribosomal RNA (rRNA) sequences from 33 globally distributed mosquito species for improved metagenomics and species identification
Total RNA sequencing (RNA-seq) is an important tool in the study of mosquitoes and the RNA viruses they vector as …
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