29 publication(s) trouvée(s)
Article scientifique
Nanoscale biointerfaces in inter-organelle communication: membrane contact sites, organelle trafficking, and cell fate control
Cellular and tissue organization depends on the spatial arrangement, ultrastructure, and functional coupling of organelles. This review reframes intracellular nanomaterials …
Article scientifique
Telomere-driven dysfunctional changes in gynecological cancers: mechanistic insights, biomarker potential, and therapeutic targeting
Telomeres are major determinants of chromosome integrity, and when poorly regulated, they have been shown to contribute critically to malignant …
Article scientifique
Heat shock protein Gp96 (Grp94) in malaria: functional insights at the host-parasite interface and therapeutic perspectives
Heat shock protein Gp96 (also known as Grp94 or endoplasmin) is the endoplasmic reticulum (ER)-resident paralog of the Hsp90 family …
Article scientifique
Prenatal alcohol exposure induces anxiety and depressive-like behaviors with deficits in growth and food intake in mice
Background/Objectives: Prenatal alcohol exposure (PAE) has been recognized as a significant public health concern due to its consequential and long-lasting …
Article scientifique
Hyperglycaemia-induced molecular reprogramming of proximal tubular epithelial cells and its contribution to diabetic kidney disease progression—a narrative review
Diabetic kidney disease (DKD) is the primary contributor to the development of chronic kidney disease and end-stage kidney failure globally. …
Article scientifique
PARP inhibitors across different malignancies: clinical applications, resistance mechanisms, and strategies to enhance efficacy through combination therapies
Poly-ADP-ribose polymerase (PARP) inhibitors represent a novel class of anticancer agents that leverage the principle of synthetic lethality to induce …
Article scientifique
High salt intake and HIV infection on endothelial glycocalyx shedding in salt-sensitive hypertension
The endothelial glycocalyx is closely associated with various physiological and pathophysiological events. Significant modification of the endothelial glycocalyx is an …
Article scientifique
Molecular mechanisms of mitochondria-mediated ferroptosis: a potential target for antimalarial interventions
Ferroptosis is an iron-dependent form of regulated cell death characterized by glutathione (GSH) depletion, glutathione peroxidase 4 (GPX4) inactivation, and …
Article scientifique
ROS induced lipid peroxidation and their role in ferroptosis
Reactive oxygen species (ROS) play a crucial part in the process of cell death, including apoptosis, autophagy, and ferroptosis. ROS …
Article scientifique
COVID-19 disease treatment: pivotal challenges in the arena of umbilical cord-mesenchymal stem cells (UC-MSCs)
This century's first major epidemic of a new coronavirus illness (2019-nCoV) was a tremendous shock to the healthcare system. The …
Article scientifique
The first-line antituberculosis drugs, and their fixed-dose combination induced abnormal sperm morphology and histological lesions in the testicular cells of male mice
Rifampicin (RIF), Isoniazid (INH), Ethambutol (EMB), Pyrazinamide (PZA), and/or their fixed-dose combination (FDC) are extensively prescribed in the cure of …
Article scientifique
The structure, biosynthesis, and biological roles of fetuin-A: A review
Fetuin-A is a heterodimeric plasma glycoprotein containing an A-chain of 282 amino acids and a B-chain of 27 amino acid …
Article scientifique
Plasmodium falciparum Molecular Chaperones: Guardians of the Malaria Parasite Proteome and Renovators of the Host Proteome
Plasmodium falciparum is a unicellular protozoan parasite and causative agent of the most severe form of malaria in humans. The …
Article scientifique
Histone Modification Landscapes as a Roadmap for Malaria Parasite Development
Plasmodium falciparum remains the deadliest parasite species in the world, responsible for 229 million cases of human malaria in 2019. …
Article scientifique
Functional Differentiation of BMP7 Genes in Zebrafish: bmp7a for Dorsal-Ventral Pattern and bmp7b for Melanin Synthesis and Eye Development
Bone morphogenetic protein 7 (BMP7) belongs to the transforming growth factor β (TGF-β) family, which not only induces cartilage and …
Article scientifique
Mechanistic Insights Delineating the Role of Cholesterol in Epithelial Mesenchymal Transition and Drug Resistance in Cancer
Despite the significant advancements made in targeted anti-cancer therapy, drug resistance constitutes a multifaceted phenomenon leading to therapy failure and …
Article scientifique
DNA Methylation of PGC-1α Is Associated With Elevated mtDNA Copy Number and Altered Urinary Metabolites in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a complex disorder that is underpinned by numerous dysregulated biological pathways, including pathways that affect …
Article scientifique
HIV-1 Transactivator of Transcription (Tat) Co-operates With AP-1 Factors to Enhance c-MYC Transcription
HIV-1 infection often leads to the development of co-morbidities including cancer. Burkitt lymphoma (BL) is one of the most over-represented …
Article scientifique
Corrigendum: In vitro Characterization of Insulin–Producing β-Cell Spheroids
Compact, intact cell aggregates were hand-picked and transferred into ProtoTissue™ bioreactors (CelVivo ApS, DK-5491 Blommenslyst, Denmark; Cat. no 010) to …
Article scientifique
Cellular and Supracellular Planar Polarity: A Multiscale Cue to Elongate the Drosophila Egg Chamber
Tissue elongation is known to be controlled by oriented cell division, elongation, migration and rearrangement. While these cellular processes have …
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