192 publication(s) trouvée(s)
Article scientifique
Correction: Green-synthesized rhein-selenium nanoparticles exhibit potent and highly selective anticancer activity against colon cancer via apoptosis and gene regulation
Correction on: Abd El-Halim, M. D., Osman, A., Ibrahim, M. A., El-Azab, M. M., El-Saber, M. M., Ismail, S. H., …
Article scientifique
Multiscale mechanistic modeling for the rational design of novel dual-target candidates against acetylcholinesterase and NADPH oxidase: an advanced computational study
Introduction: Alzheimer's disease is a complex neurodegenerative illness strongly associated with oxidative stress, which requires immediate intervention for therapeutic agents …
Article scientifique
Sequential soxhlet fractionation of Cistus ladanifer L. reveals a polarity–activity gradient: GC-MS profiling, multimechanistic bioactivity, and in silico identification of antifungal and antibacterial lead compounds
Introduction AMR and oxidative stress are among the most pressing biomedical challenges, requiring structurally novel multi-target bioactive molecules. Cistus ladanifer …
Article scientifique
Biosorption of Pb(II), Cu(II), and Zn(II) from aqueous solutions using unmodified coconut husk: characterization, adsorption equilibrium, and kinetic studies
Introduction Heavy-metal contamination of water and wastewater is a persistent environmental challenge because metallic pollutants are non-biodegradable, bioaccumulate through food …
Article scientifique
Enhanced detection of pennyroyal essential oil adulteration using FTIR spectroscopy and chemometrics
Introduction The essential oil of pennyroyal has a number of bioactive properties, including antiviral, antifungal, and anti-inflammatory effects. Accurate, rapid, …
Article scientifique
Integrated in silico and experimental evaluation of enhanced antioxidant effects of Mentha species using mixture design methodology
The search for strongly effective and safe antioxidants is still one of the most important objectives targeted by the food …
Article scientifique
Linking phytochemistry to bioactivity: in vitro, in vivo, and in silico insights into Rubia tinctorum
Introduction This study investigated the phytochemical composition and biological activities of the aqueous root extract of Rubia tinctorum L. using …
Article scientifique
Correction: Methotrexate-lactoferrin targeted exemestane cubosomes for synergistic breast cancer therapy
Correction on: Mokhtar S, Khattab SN, Elkhodairy KA, Teleb M, Bekhit AA, Elzoghby AO and Sallam MA (2022) Methotrexate-Lactoferrin Targeted …
Article scientifique
Phytochemical profiling and multi-target pharmacological evaluation of Symphyotrichum squamatum unveils its potential as a source of antidiabetic and anti-inflammatory agents
Introduction This study aimed to thoroughly profile the phytochemicals and pharmacological properties of Symphyotrichum squamatum's aerial parts to assess its …
Article scientifique
Sustainable dye removal using fish scale-derived biosorbent: performance and mechanisms
Introduction: In the context of sustainable methodologies for wastewater remediation, this study focuses on the development of an efficient and …
Article scientifique
Emerging insights into chemistry and therapeutic potentials of functionalized hexahydroquinolines
Quinolines are well-established scaffolds in drug discovery and form the core of many FDA-approved medicines. Among their reduced analogues, hexahydroquinolines …
Article scientifique
Green-synthesized rhein-selenium nanoparticles exhibit potent and highly selective anticancer activity against colon cancer via apoptosis and gene regulation
Introduction: Colon cancer remains a major global health challenge, necessitating the development of novel, selective, and sustainable therapeutic strategies. Rhein, …
Article scientifique
Extraction of phenolic compounds and flavonoids from tomato residues using high-pressure-temperature advanced method
Tomato residues in the Agadir region constitute a large and under-exploited source of biomass, rich in bioactive molecules such as …
Article scientifique
Evaluation of the phytochemical profile, biological activities, and acute toxicity of Cistus ladanifer aerial part extracts: experimental and in silico investigations
Introduction Using both experimental and in silico approaches, this study aimed to evaluate the phytochemical composition and biological activities of …
Article scientifique
Structure-based molecular modeling of a novel S-Remiketamine scaffold and derived arylcyclohexanone analogues: NMDA receptor dynamics, MM-GBSA ranking, and CES1-Oriented structural compatibility
Introduction: Short-acting ketamine-related scaffold design remains an important medicinal-chemistry problem, but computational studies require conservative interpretation until receptor, enzymatic, and …
Article scientifique
Rheum officinale Baill.: chemical characterization and in-vitro biological activities
Medicinal plants constitute a valuable natural resource of bioactive phytochemicals, which are increasingly studied for their therapeutic potential and broad …
Article scientifique
Deep learning-guided discovery of selective JAK2-JH2 allosteric inhibitors: integration of MLP predictive modeling, BREED-based library design, and computational validation
The JAK2 pseudokinase domain (JH2) is an important therapeutic target in hematologic and oncologic diseases, motivating the search for selective …
Article scientifique
Regioselective synthesis of novel spiro-isoxazolines congeners as antimicrobial agents: in vitro and in-silico assessments
Introduction A new class of spiroisoxazolines was efficiently synthesized through a regioselective cycloaddition between arylidene tetralone 1 and arylnitrile oxides …
Article scientifique
Preparation of biosorbent from avocado seeds for preconcentration and simultaneous extraction of trace parabens in environmental wastewater samples
The identification of emerging contaminants, including parabens, in water resources and aquatic ecosystems has become an issue of environmental concern …
Article scientifique
Synthesis, structural characterization, spectroscopic analyses, DFT-modeling, and RDG-NCI assessment of 4-dimethylaminopyridinium dihydrogen monophosphate
was synthesized and characterized. The intra-and intermolecular interactions responsible for the stability of our compound within the crystal lattice have …
1 / 10
Suivant →