471 publication(s) trouvée(s)
Article scientifique
Comparative serum cytokine and chemokine profiles across tuberculosis, latent TB, HIV, and COVID-19 infections in Namibian adults
Background The devastating pandemic of coronavirus disease 2019 (COVID-19) highlighted the importance of early detection and global collaboration in combating …
Article scientifique
Benzo[a]pyrene-induced immunotoxicity, neurotoxicity, and cardiotoxicity in grass carp (Ctenopharyngodon idella)
Introduction Benzo[a]pyrene (B[a]P), a widespread polycyclic aromatic hydrocarbon (PAH), is a major aquatic pollutant with known toxic effects. However, its …
Article scientifique
Major histocompatibility complex class II deficiency in Morocco: a 26-year retrospective cohort study
Major histocompatibility complex class II (MHC-II) deficiency is a rare autosomal recessive combined immunodeficiency caused by defects in transcriptional regulators …
Article scientifique
Forkhead box O3 transcription factor fine-tunes IL-6 expression in mycobacteria-infected macrophages
Introduction Tuberculosis (TB) remains the deadliest infectious disease in humans; however, a robust immune response can either protect against or …
Article scientifique
Pre-vaccination biomarkers of enteric dysfunction, inflammation and nutritional status associate with seroconversion to oral cholera vaccine and are perturbed during natural infection
Background Oral cholera vaccines (OCVs) show variable immunogenicity in endemic settings. Host factors including enteric dysfunction, systemic inflammation, and nutritional …
Article scientifique
Editorial: The role of vitamin D as an immunomodulator, volume III
Vitamin D is a pleiotropic secosteroid hormone that extends far beyond its classical role in calcium and phosphate homeostasis to …
Article scientifique
Genetic and autoimmune predispositions to fulminant viral hepatitis in children
Fulminant viral hepatitis (FVH) in children is a rare but often fatal form of acute liver failure occurring in the …
Article scientifique
Case Report: Compound heterozygous ITGB2 variants causing leukocyte adhesion deficiency type I With preserved CD18 expression
Introduction Leukocyte adhesion deficiency (LAD) type I is a well-recognized inborn error of immunity that typically presents in early childhood. …
Article scientifique
Editorial: Diseases with immune dysregulation in Africa
Immune dysregulation encompasses a broad spectrum of disorders, including inborn errors of immunity (IEIs), autoimmune and autoinflammatory diseases, allergic disorders, …
Article scientifique
Long non-coding RNAs in glioblastoma: from molecular drivers to therapeutic targets
Glioblastoma (GBM) is the most aggressive primary malignant brain tumor in adults and remains associated with poor clinical outcomes despite …
Article scientifique
HLA-C polymorphisms with susceptibility and protection against acute leukemia in a Moroccan population
Background Acute leukemia (AL) is a malignant hematological disorder, with two main subtypes: acute myeloid leukemia (AML) and acute lymphoblastic …
Article scientifique
Reservoir differences across HIV-1 subtypes: a systematic review to guide cure research
Introduction: Despite effective antiretroviral therapy, HIV-1 persists as a viral reservoir and remains a major barrier to a durable cure. …
Article scientifique
A cross-sectional study reveals complex associations between gastrointestinal parasite composition and faecal immune and inflammatory biomarkers in wildlife and livestock in Kenya
Background In landscapes where wildlife and livestock co-graze, hosts are often poly-parasitised with diverse nematode and protozoan communities. The relationships …
Article scientifique
Maternal inflammation disrupts transplacental antibody transfer in pregnant individuals with and without HIV
Introduction: Maternally transferred immunity plays a critical role in protecting infants from pathogens during the vulnerable period before their own …
Article scientifique
Hepatic granulomas as a manifestation of ANCA-associated vasculitis:a systematic review
Background: ANCA-associated vasculitides (AAV) - granulomatosis with polyangiitis (GPA), eosinophilic granulomatosis with polyangiitis (EGPA), and microscopic polyangiitis (MPA) - are …
Article scientifique
Host genetics influences HIV reservoir persistence, treatment outcomes and CCR5 expression in patients on long-term antiretroviral therapy in Ghana
Objective This study investigated influence of cysteine-cysteine chemokines (CCR5, CCR5-59029A/G, CCR2), and stoma cell derived factor 1 (SDF1); as AIDS …
Article scientifique
Designing an integrated data model for prospective genotype-phenotype in inborn errors of immunity research
Background: Inborn errors of immunity are rare, genetically heterogeneous disorders requiring coordinated clinical, laboratory, and genetic evaluation over time. Data …
Article scientifique
Systemic and mucosal immunity to enterotoxigenic Escherichia coli: evidence from natural infection and vaccination
(ETEC) is a major contributor to diarrheal morbidity and mortality, especially among children under 5 years of age in low- …
Article scientifique
Correction: Shared germline-biased plasmablast clonotypes shape early neutralizing antibody responses during acute Chikungunya virus infection
[This corrects the article DOI: 10.3389/fimmu.2026.1846926.].
Article scientifique
Auto-antibodies neutralizing type I interferons in ~10% of Moroccan patients with life-threatening COVID-19
Introduction: Autoantibodies neutralizing type I interferon (AAN-I-IFN) have been found in at least 10-15% of critical COVID-19 pneumonia cases in …
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