471 publication(s) trouvée(s)
Article scientifique
The subdued post-boost spike-directed secondary IgG antibody response in Ugandan recipients of the Pfizer-BioNTech BNT162b2 vaccine has implications for local vaccination policies
Introduction: This study aimed to delineate longitudinal antibody responses to the Pfizer-BioNTech BNT162b2 COVID-19 vaccine within the Ugandan subset of …
Article scientifique
Cytokine gene polymorphisms implicated in the pathogenesis of Plasmodium falciparum infection outcome
Cytokines play a critical role in the immune mechanisms involved in fighting infections including malaria. Polymorphisms in cytokine genes may …
Article scientifique
Gut microbiota-gonadal axis: the impact of gut microbiota on reproductive functions
The influence of gut microbiota on physiological processes is rapidly gaining attention globally. Despite being under-studied, there are available data …
Article scientifique
Microbial evasion of the complement system: a continuous and evolving story
The complement system is a fundamental part of the innate immune system that plays a key role in the battle …
Article scientifique
Recent advances in understanding the human host immune response in tuberculous meningitis
Tuberculous meningitis (TBM), the most severe form of tuberculosis, causes death in approximately 25% cases despite antibiotic therapy, and half …
Article scientifique
A metabolic perspective of the neutrophil life cycle: new avenues in immunometabolism
Neutrophils are the most abundant innate immune cells. Multiple mechanisms allow them to engage a wide range of metabolic pathways …
Article scientifique
Divergent neuroimmune signatures in the cerebrospinal fluid predict differential gender-specific survival among patients with HIV-associated cryptococcal meningitis
Introduction: Survival among people with HIV-associated cryptococcal meningitis (CM) remains low, particularly among women, despite the currently optimal use of …
Article scientifique
Feasibility and acceptability of undertaking postmortem studies for tuberculosis medical research in a low income country
Introduction: If we are to break new ground in difficult-to-treat or difficult-to-vaccinate diseases (such as HIV, malaria, or tuberculosis), we …
Article scientifique
Immunogenicity of PE18, PE31, and PPE26 proteins from Mycobacterium tuberculosis in humans and mice
Introduction: . In this study, we explored the immunogenicity of three proteins from this family, PE18, PE31, and PPE26, in …
Article scientifique
Microbiota dynamics, metabolic and immune interactions in the cervicovaginal environment and their role in spontaneous preterm birth
Differences in the cervicovaginal microbiota are associated with spontaneous preterm birth (sPTB), a significant cause of infant morbidity and mortality. …
Article scientifique
Inflammatory immune profiles associated with disease severity in pulmonary tuberculosis patients with moderate to severe clinical TB or anemia
Background Immune control of Mycobacterium tuberculosis (Mtb) infection is largely influenced by the extensive disease heterogeneity that is typical for …
Article scientifique
Acquisition of complement fixing antibodies targeting Plasmodium falciparum merozoites in infants and their mothers in Uganda
Background Antibody-mediated complement fixation has previously been associated with protection against malaria in naturally acquired immunity. However, the process of …
Article scientifique
Immune activation and inflammation in lactating women on combination antiretroviral therapy: role of gut dysfunction and gut microbiota imbalance
Introduction Combination antiretroviral therapy (cART) effectively controls HIV; however, chronic low-level viremia and gut microbiota dysbiosis remain significant drivers of …
Article scientifique
Sustained spike-specific IgG antibodies following CoronaVac (Sinovac) vaccination in sub-Saharan Africa, but increased breakthrough infections in baseline spike-naive individuals
Introduction: This study investigated the antibody responses to the inactivated COVID-19 vaccine, CoronaVac (Sinovac Biotech) in the African population to …
Article scientifique
Safety and immunogenicity of BK-SE36/CpG malaria vaccine in healthy Burkinabe adults and children: a phase 1b randomised, controlled, double-blinded, age de-escalation trial
Background: serine repeat antigen5 (SE36), adsorbed to aluminium hydroxide gel and reconstituted, prior to administration, with synthetic oligodeoxynucleotides bearing CpG …
Éditorial
Editorial: The immunological role of platelet activation in the pathophysiology of COVID-19
Platelets are increasingly recognized for their role as mediators of immune response and inflammation. As major components of the hematological …
Article scientifique
Dried urine spot method for detection of Schistosoma mansoni circulating cathodic antigen in resource-limited settings: a proof of concept study
Background: Among the challenges in schistosomiasis surveillance and mapping surveys is the lack of a sensitive diagnostic method especially in …
Article scientifique
Soluble biomarkers of HIV-1-related systemic immune activation are associated with high plasma levels of growth factors implicated in the pathogenesis of Kaposi sarcoma in adults
Background Human Herpesvirus-8 (HHV-8) is the etiologic agent of Kaposi’s sarcoma (KS), a multicentric angio-proliferative cancer commonly associated with Human …
Article scientifique
Inflammatory profile of vertically HIV-1 infected adolescents receiving ART in Cameroon: a contribution toward optimal pediatric HIV control strategies
Antiretroviral therapy (ART) has improved the lifespan of people living with HIV. However, their immune system remains in a state …
Article scientifique
Dynamics of IgG antibody response against Plasmodium antigens among Nigerian infants and young children
Background Plasmodium falciparum malaria is a leading cause of child mortality in Nigeria. Neonates are born with maternal antibodies from …