471 publication(s) trouvée(s)
Article scientifique
Negative association between ascaris lumbricoides seropositivity and Covid-19 severity: insights from a study in Benin
Introduction: The COVID-19 pandemic has had devastating effects worldwide, but the trajectory of the pandemic has been milder in Low-and-Middle-Income …
Article scientifique
The immune checkpoint VISTA is associated with prognosis in patients with malignant uveal melanoma
Introduction: Uveal melanoma (UM) is a rare yet deadly tumor. It is known for its high metastatic potential, which makes …
Article scientifique
Development of conjugated secondary antibodies for wildlife disease surveillance
Disease monitoring in free-ranging wildlife is a challenge and often relies on passive surveillance. Alternatively, proactive surveillance that relies on …
Article scientifique
NR2F6, a new immune checkpoint that acts as a potential biomarker of immunosuppression and contributes to poor clinical outcome in human glioma
Intoroduction: Nuclear receptor subfamily 2 group F member 6 (NR2F6) is a promising checkpoint target for cancer immunotherapy. However, there …
Article scientifique
Suppressive myeloid cells in SARS-CoV-2 and Mycobacterium tuberculosis co-infection
(Mtb) infection after recent SARS-CoV-2. A shared dysregulation of immunity explains the dual risk posed by co-infection, but the specific …
Article scientifique
Fc receptors act as innate immune receptors during infection?
Innate immunity constitutes the first nonspecific immunological line of defense against infection. In this response, a variety of mechanisms are …
Article scientifique
Clinical and immunological spectra of human cutaneous leishmaniasis in North Africa and French Guiana
Cutaneous leishmaniasis (CL) caused by infection with the parasite Leishmania exhibits a large spectrum of clinical manifestations ranging from single …
Article scientifique
Consequences of HIV infection in the bone marrow niche
Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV infection contributes to haematological abnormalities …
Article scientifique
Vimentin: from a cytoskeletal protein to a critical modulator of immune response and a target for infection
Vimentin is an intermediate filament protein that plays a role in cell processes, including cell migration, cell shape and plasticity, …
Article scientifique
Frequent IgE recognition of Blomia tropicalis allergen molecules in asthmatic children and young adults in equatorial Africa
Background Asthma is not well investigated in equatorial Africa and little is known about the disease-associated allergen molecules recognized by …
Article scientifique
Association of Human Leukocyte Antigen (HLA) class II (DRB1 and DQB1) alleles and haplotypes with Rheumatoid Arthritis in Sudanese patients
The aim of this study was to determine the Human Leukocyte Antigen (HLA) class II (DRB1 and DQB1) alleles and …
Article scientifique
Human immunodeficiency virus and antiretroviral therapy-mediated immune cell metabolic dysregulation in children born to HIV-infected women: potential clinical implications
Commencing lifelong antiretroviral therapy (ART) immediately following HIV diagnosis (Option B+) has dramatically improved the health of HIV-infected women and …
Éditorial
Editorial: Neuroimmunology in Africa
In the 1970s and 1980s, neuroscience research appeared sporadically in North and South Africa in the form of isolated publications …
Article scientifique
Genetically confirmed chronic granulomatous disease in a Kenyan child: case report
Introduction We report the first case of genetically confirmed chronic granulomatous disease (CGD) in a Kenyan child. Clinical findings A …
Article scientifique
A systems serology approach to the investigation of infection-induced antibody responses and protection in trachoma
Background Ocular infections with Chlamydia trachomatis serovars A–C cause the neglected tropical disease trachoma. As infection does not confer complete …
Article scientifique
Is TNF alpha a mediator in the co-existence of malaria and type 2 diabetes in a malaria endemic population?
Malaria remains a disease of public health importance globally, especially in sub-Saharan Africa. Malaria deaths reduced globally steadily between 2000-2019, …
Article scientifique
Seroprevalence and durability of antibody responses to AstraZeneca vaccination in Ugandans with prior mild or asymptomatic COVID-19: implications for vaccine policy
Introduction: The duration and timing of immunity conferred by COVID-19 vaccination in sub-Saharan Africa are crucial for guiding pandemic policy …
Article scientifique
TMIGD2 as a potential therapeutic target in glioma patients
Introduction: Among all types of central nervous system cancers, glioma remains the most frequent primary brain tumor in adults. Despite …
Article scientifique
Environmental and microbial factors influence affective and cognitive behavior in C57BL/6 sub-strains
C57BL/6 mice are one of the most widely used inbred strains in biomedical research. Early separation of the breeding colony …
Article scientifique
Pre-pandemic SARS-CoV-2-specific IFN-γ and antibody responses were low in Ugandan samples and significantly reduced in HIV-positive specimens
Introduction: We investigated whether prior SARS-CoV-2-specific IFN-γ and antibody responses in Ugandan COVID-19 pre-pandemic specimens aligned to this population's low …