46 publication(s) trouvée(s)
Article scientifique
Association between the subcellular localization of host proteins and gut microbiome and metabolome in metabolic dysfunction-associated steatotic liver disease: a pilot study
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is estimated to affect 38% of the global population, with limited options for …
Article scientifique
Insights from LC-MS-based cerebrospinal fluid metabolomics in tuberculous meningitis
Tuberculous meningitis (TBM) remains the most devastating form of extra-pulmonary tuberculosis (TB) and is associated with high mortality and neurological …
Article scientifique
Investigating circulating expression profile for H19, MEG3, and MIAT long noncoding RNAs with miR-135a and miR-29a in chronic kidney disease and renal hemodialysis patients: interrelations with serum sclerostin
Background and aim Chronic kidney disease (CKD) incorporates a variety of progressive kidney function declines, ranging from mild impairment to …
Article scientifique
Pyrrolopyrimidine derivatives as dual COX-2/ACE2 inhibitors: design, synthesis, and anti-inflammatory evaluation
In this study, we report the design and synthesis of a new series of pyrrolopyrimidine derivatives developed as dual-target nonsteroidal …
Article scientifique
Isolation, characterization, and biological evaluation of endophytic fungi from Phragmites australis: experimental and computational insights
Endophytic fungi are an uncharted source of bioactive metabolites with varied therapeutic characteristics. In this research, an endophytic Aspergillus sp. …
Article scientifique
Pharmacophore modeling: advances and pitfalls
Pharmacophore modeling has evolved from a static conceptual framework into a central computational tool in modern drug discovery. Recent advances …
Article scientifique
Correction: Anticarcinogenic cationic peptides derived from tryptic hydrolysis of β-lactoglobulin
Corrigendum: Anticarcinogenic cationic peptidesderived from tryptic hydrolysis of β-lactoglobulin* Correspondence: basel.sitohy@umu.seKeywords: β-lactoglobulin, trypsin, antioxidant activity, anticancer activity, caspase, VEGFR-2Corrigendum on: …
Article scientifique
Urinary metabolic characterization of advanced tuberculous meningitis cases in a South African paediatric population
Tuberculous meningitis (TBM) is a severe form of tuberculosis with high neuro-morbidity and mortality, especially among the paediatric population (aged …
Article scientifique
Circulating miR-206, miR-181b, and miR-21 as promising biomarkers in hypothyroidism and their relationship to related hyperlipidemia and hepatic steatosis
Background: Thyroid hormones (THs) signaling has profound effects on many physiological processes. The regulation of THs signaling in various tissues …
Article scientifique
Zinc phthalocyanine loaded- antibody functionalized nanoparticles enhance photodynamic therapy in monolayer (2-D) and multicellular tumour spheroid (3-D) cell cultures
In conventional photodynamic therapy (PDT), effective delivery of photosensitizers (PS) to cancer cells can be challenging, prompting the exploration of …
Article scientifique
Chemical profiling and dermatological and anti-aging properties of Syzygium jambos L. (Alston): evidence from molecular docking, molecular dynamics, and in vitro experiments
The phytoconstituents of the aqueous extract from Syzygium jambos L. (Alston) leaves were defined using HPLC-PDA-MS/MS and the antioxidant, anti-aging, …
Article scientifique
Potent VEGFR-2 inhibitors for resistant breast cancer: a comprehensive 3D-QSAR, ADMET, molecular docking and MMPBSA calculation on triazolopyrazine derivatives
More people are being diagnosed with resistant breast cancer, increasing the urgency of developing new effective treatments. Several lines of …
Article scientifique
Unleashing Nature’s potential: a computational approach to discovering novel VEGFR-2 inhibitors from African natural compound using virtual screening, ADMET analysis, molecular dynamics, and MMPBSA calculations
One of the characteristic features of cancer is angiogenesis, the process by which new, aberrant blood vessels are formed from …
Article scientifique
Hydroxyurea pharmacokinetics and precision dosing in low-resource settings
Introduction: Hydroxyurea is effective disease-modifying treatment for sickle cell anemia (SCA). Escalation to maximum tolerated dose (MTD) achieves superior benefits …
Article scientifique
Polycladia myrica-based delivery of selenium nanoparticles in combination with radiotherapy induces potent in vitro antiviral and in vivo anticancer activities against Ehrlich ascites tumor
Background: Over the last few decades, nanotechnology has entered daily life through various applications, therefore, there has been a trend …
Article scientifique
Corrigendum: KODAMA exploratory analysis in metabolic phenotyping
In the published article, there was an error in affiliations of Leonardo Tenori. Instead of “5,6”, it should be “6,7”. …
Article scientifique
Preliminary insights on the metabolomics of Trichinella zimbabwensis infection in Sprague Dawley rats using GCxGC-TOF-MS (untargeted approach)
Trichinella infections have been documented globally and have been detected in wild and/or domestic animals except Antarctica. There is paucity …
Article scientifique
KODAMA exploratory analysis in metabolic phenotyping
KODAMA is a valuable tool in metabolomics research to perform exploratory analysis. The advanced analytical technologies commonly used for metabolic …
Article scientifique
ADMET profiling and molecular docking of potential antimicrobial peptides previously isolated from African catfish, Clarias gariepinus
Amidst rising cases of antimicrobial resistance, antimicrobial peptides (AMPs) are regarded as a promising alternative to traditional antibiotics. Even so, …
Article scientifique
Editorial: Molecular chaperones and human disease
EDITORIAL article Front. Mol. Biosci., 17 November 2022Sec. Molecular Diagnostics and Therapeutics https://doi.org/10.3389/fmolb.2022.1068238
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