220 publication(s) trouvée(s)
Article scientifique
Prognostic impact of CD123 overexpression on the outcome of pediatric acute myeloid leukemia
Background and aims Despite advances in acute myeloid leukemia (AML) therapy, outcomes remain poor. CD123 overexpression influences proliferation and enhanced …
Article scientifique
Immunotherapy in urological cancers: new paradigms and a systematic review of clinical trials and real-world evidence
Introduction: The therapeutic landscape of urological cancers has undergone a paradigm shift with the advent of immunotherapy. This systematic review …
Article scientifique
Case Report: Fatal convergence of two confirmed and one radiologically suspected synchronous urological malignancies in a young patient: ultra-late clear cell renal cell carcinoma recurrence, contralateral renal tumor, and metastatic prostate cancer
Introduction: The simultaneous presentation of multiple primary urological malignancies in a single patient is exceedingly rare and poses significant diagnostic …
Article scientifique
Cancer outcomes and biological mechanisms among patients with type 2 diabetes mellitus using glucagon-like peptide-1 receptor agonists: a systematic review and meta-analysis
Introduction: While glucagon-like peptide-1 receptor agonists (GLP-1RAs) provide metabolic and cardiovascular benefits in type 2 diabetes mellitus (T2DM) patients, uncertainty …
Article scientifique
Genome-wide association study identifies and validates genetic variation in the RIG-I/MAVS signaling pathway associated with HIV-related Kaposi sarcoma in children and adults
Introduction Immune deficiency and infection with human herpesvirus-8 (HHV-8) are established component causes of Kaposi sarcoma (KS), but they are …
Article scientifique
Management challenges in metachronous bilateral breast cancer with discordant receptor status: a case report
Background: Bilateral breast cancer is uncommon, accounting for 2%-5% of cases, and presents additional clinical challenges when tumors exhibit discordant …
Article scientifique
Effects of surgery on cancer metastasis: biological mechanisms and perioperative implications
Cancer metastasis remains the leading cause of cancer-related mortality, and the perioperative period has emerged as a critical window during …
Article scientifique
Association between HPV-16 and HPV-18 viral loads and severity of cervical pre-invasive lesions in women with and without HIV in Botswana
Background: Cervical cancer is an important global health problem, including in Botswana. Human papillomavirus (HPV) and human immunodeficiency virus (HIV) …
Article scientifique
Structural and functional hepatic factors as prognostic indicators in children with Langerhans cell histiocytosis
Background and aim: Langerhans cell histiocytosis (LCH) is a clonal myeloid neoplasm with variable outcomes; hepatic involvement is uniformly classified …
Article scientifique
Artificial intelligence-assisted radiotherapy for pelvic and abdominal malignancies: assessing feasibility in the context of Africa-specific risks
Cancer care in Africa remains severely limited, with pelvic and abdominal malignancies contributing substantially to the disease burden. Radiotherapy is …
Article scientifique
Case Report: Definitive radiotherapy for inoperable anal Buschke–Löwenstein tumors: two cases with literature review
Background: Buschke-Löwenstein tumors (BLTs), also known as giant condyloma acuminatum, are rare HPV-related lesions with benign histology but locally aggressive …
Article scientifique
RBBP6 and cancer: from molecular mechanisms to clinical implications
Retinoblastoma binding protein 6 (RBBP6) is a 200 kDa E3 ubiquitin ligase that performs several biological functions and plays a …
Article scientifique
Breast and cervical cancer screening in a semi-urban African setting: evidence from Franceville, Gabon (2015–2021)
Background: Breast and cervical cancers are among the most frequent malignancies in women worldwide and represent a growing public health …
Article scientifique
Efficacy and safety of hypofractionated versus conventional radiotherapy in breast cancer: a systematic review and meta-analysis
Background: Breast cancer is one of the most frequent cancers globally, and radiotherapy plays an important key role in reducing …
Article scientifique
Hemozoin-induced immunomodulation and prostate carcinogenesis: mechanisms and implications
Hemozoin (Hz) is a crystalline by-product, which is produced when the Plasmodium species destroy haemoglobin, and it is commonly recognised …
Article scientifique
Burden, clinical characteristics, and management patterns of prostate cancer in Nigeria: a systematic review and meta-analysis
Background Prostate cancer is one of the most common types of cancer morbidity and mortality among Nigerian men, but there …
Article scientifique
Novel transcriptomic alterations in poorly differentiated endometrial carcinomas: evidence from South African women
Background: Poorly differentiated endometrial carcinoma in Black African women is under-characterized at the transcriptomic level, although it is known for …
Article scientifique
Unravelling prostate cancer risk and protective factors among urology patients in a Tanzanian population
Background: Prostate cancer (PCa) is a leading cause of cancer-related morbidity and mortality among men globally. The prevalence is disproportionate …
Article scientifique
Gastric cancer in Abidjan: care strategies and survival in a resource-limited setting
Background: In Côte d'Ivoire, the management of gastric cancer relies mainly on chemotherapy and surgery. However, the actual impact of …
Article scientifique
Promising outcomes of R-CHOP therapy in pediatric nodular lymphocyte-predominant Hodgkin lymphoma: perspectives from a rare subtype
Background: Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare sub-type of Hodgkin lymphoma (HL). Due to its rarity, the …
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