220 publication(s) trouvée(s)
Article scientifique
Understanding the Complex Milieu of Epithelial-Mesenchymal Transition in Cancer Metastasis: New Insight Into the Roles of Transcription Factors
Epithelial-mesenchymal transition (EMT) is a physiological program during which polarised, immobile epithelial cells lose connection with their neighbours and are …
Article scientifique
Mitochondrial Effects on Seeds of Cancer Survival in Leukemia
The cancer metabolic alteration is considered a hallmark and fast becoming a road for therapeutic intervention. Mitochondria have been regarded …
Article scientifique
Use of Machine Learning and Statistical Algorithms to Predict Hospital Length of Stay Following Colorectal Cancer Resection: A South African Pilot Study
The aim of this pilot study was to develop logistic regression (LR) and support vector machine (SVM) models that differentiate …
Article scientifique
Inexpensive Systemic Inflammatory Biomarkers in Ovarian Cancer: An Umbrella Systematic Review of 17 Prognostic Meta-Analyses
The association of several inflammation-based biomarkers [lymphocyte-to-monocyte, neutrophil-to-lymphocyte, and platelet-to-lymphocyte ratios (LMR, NLR, and PLR, respectively)] with the survival of …
Article scientifique
Carotenoid-Enriched Fractions From Spondias mombin Demonstrate HER2 ATP Kinase Domain Inhibition: Computational and In Vivo Animal Model of Breast Carcinoma Studies
Human epidermal growth factor 2 (HER2) is overexpressed in about 20% of breast cancer and is associated with a poor …
Article scientifique
Identification of Eleven Novel BRCA Mutations in Tunisia: Impact on the Clinical Management of BRCA Related Cancers
Background Breast cancer is the world’s most common cancer among women. It is becoming an increasingly urgent problem in low- …
Article scientifique
MDM2/X Inhibitors as Radiosensitizers for Glioblastoma Targeted Therapy
Inhibition of the MDM2/X-p53 interaction is recognized as a potential anti-cancer strategy, including the treatment of glioblastoma (GB). In response …
Article scientifique
Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance
Pancreatic cancer is one of the most deadly cancers, ranking amongst the top leading cause of cancer related deaths in …
Article scientifique
The Tumor Microenvironment Factors That Promote Resistance to Immune Checkpoint Blockade Therapy
Through genetic and epigenetic alterations, cancer cells present the immune system with a diversity of antigens or neoantigens, which the …
Article scientifique
Vitamin D: Possible Therapeutic Roles in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a unique type of liver cancer instigated by underlying liver diseases. Pre-clinical evidence suggests that HCC …
Article scientifique
Expression of Myoglobin in Normal and Cancer Brain Tissues: Correlation With Hypoxia Markers
BACKGROUND: Myoglobin (MB) is increasingly recognized as a key player in cancer growth and metastasis. Low oxygen tensions, commonly associated …
Article scientifique
Cancer in Africa: The Untold Story
BACKGROUND: Despite rising incidence and mortality rates in Africa, cancer has been given low priority in the research field and …
Article scientifique
Survival Status of Esophageal Cancer Patients and its Determinants in Ethiopia: A Facility Based Retrospective Cohort Study
BACKGROUND: Globally, the incidence and mortality due to esophageal cancer are increasing, particularly in low- and middle-income countries. Cancer of …
Article scientifique
Promoter Hypermethylation Analysis of Host Genes in Cervical Cancer Patients With and Without Human Immunodeficiency Virus in Botswana
Background: Epidemics of human immunodeficiency virus (HIV) and cervical cancer are interconnected. DNA hypermethylation of host genes' promoter in cervical …
Article scientifique
Globally Rare BRCA2 Variants With Founder Haplotypes in the South African Population: Implications for Point-of-Care Testing Based on a Single-Institution BRCA1/2 Next-Generation Sequencing Study
Breast cancer patients historically benefitted from population-based genetic research performed in South Africa, which led to the development of founder-based …
Article scientifique
The Promising IgSF11 Immune Checkpoint Is Highly Expressed in Advanced Human Gliomas and Associates to Poor Prognosis
Glioma is the most prevalent primary brain tumor. Immune checkpoint blockade has made a great stride in mending patient’s clinical …
Article scientifique
A Review of Cancer Genetics and Genomics Studies in Africa
Cancer is the second leading cause of death globally and is projected to overtake infectious disease as the leading cause …
Article scientifique
Cancer Omics in Africa: Present and Prospects
During the last century, cancer biology has been arguably one of the most investigated research fields. To gain deeper insight …
Article scientifique
GPI-AP: Unraveling a New Class of Malignancy Mediators and Potential Immunotherapy Targets
With millions of cases diagnosed annually and high economic burden to cover expensive costs, cancer is one of the most …
Article scientifique
Cancer in Africa: Is It a Genetic or Environmental Health Problem?
Patients of African ancestry have the poorest outcome and the shortest survival rates from cancer globally. This could be attributed …