485 publication(s) trouvée(s)
Article scientifique
Pharmacological characterization and nephroprotective potential of venoms from three egyptian scorpion species
Introduction: Scorpion venoms are complex natural mixtures rich in bioactive molecules with emerging pharmacological relevance. Drug-induced kidney injury, particularly from …
Article scientifique
Synergistic effects of intradialytic concurrent training and melatonin supplementation on immune cell adaptations in hemodialysis patients
Background Immune dysfunction and chronic low-grade inflammation contribute substantially to morbidity and cardiovascular risk in patients undergoing hemodialysis (HD). Both …
Article scientifique
Digital health in clinical pharmacy practice: transforming precision medicine and pharmacometrics in Africa
African nations still struggle with several healthcare challenges such as high prevalence of communicable and non-communicable diseases, underdeveloped healthcare systems, …
Article scientifique
Longitudinal patient-reported outcomes and predictors of improvement in chemotherapy-induced peripheral neuropathy a secondary analysis of a randomized trial
Background: Chemotherapy-induced peripheral neuropathy (CIPN) compromises function and quality of life (QoL) and may precipitate chemotherapy modification. We evaluated longitudinal …
Article scientifique
The urgent need to integrate infectious diseases expertise into the management of cancer patients with infections in sub-Saharan Africa in the era of antimicrobial resistance: a policy brief
Antimicrobial resistance (AMR) is a global health concern. Cancer patients are 1.5-2 times more likely to be affected by AMR …
Article scientifique
Tissue-specific untargeted 1H-NMR metabolomics reveals no adverse metabolic effects of daily intrabuccal cannabidiol (CBD) in healthy mice
Background Cannabidiol (CBD) has attracted renewed scientific attention for its therapeutic potential in human metabolism. However, the metabolic effects of …
Article scientifique
Comparative efficacy of free and PNAGA-encapsulated antimalarial drugs: temperature-dependent modulation of Plasmodium falciparum growth
Introduction: Poly(N-acryloyl glycinamide) (PNAGA) was evaluated as a temperature-responsive carrier for antimalarial drugs. Methods: PNAGA was synthesized and characterized by …
Article scientifique
Pharmacological activities of Xanthosoma sagittifolium (L.) Schott and Corchorus olitorius L. extracts in uterine leiomyoma: evidence from in vitro and in vivo approaches
Introduction Uterine fibroids (leiomyomas) are benign uterine tumors common in reproductive years. Metabolic syndrome—marked by obesity, insulin resistance, hypertension, and …
Article scientifique
International expert perspectives on pharmacogenomics in pharmacy education: a qualitative study with implications for South Africa
Introduction: Pharmacogenomics (PGx) has the potential to transform healthcare in South Africa through the delivery of precision medicine. However, the …
Article scientifique
Buspirone attenuates cyclophosphamide-induced renal dysfunction in association with alterations in miR-205/EGLN2, Nrf2, and PERK/ATF4/CHOP signaling
Background Although microRNAs have been investigated, the reno-protective role of microRNA-205 (miR-205) in cyclophosphamide (CPA)-induced nephrotoxicity has not yet been …
Article scientifique
Correction: Supplementation of Saussurea costus root alleviates sodium nitrite-induced hepatorenal toxicity by modulating metabolic profile, inflammation, and apoptosis
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Article scientifique
From bench to bedside: experimental pharmacology approaches to overcome bioavailability, stability, and translational barriers of bioactive peptides from natural sources
Background: Bioactive peptides derived from natural sources (marine organisms, plants, microbes, and fermented foods) exhibit potent antimicrobial, antihypertensive, antioxidant, and …
Article scientifique
Neurogenesis and neuroplasticity activities of natural products: therapeutic potential in Alzheimer’s disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and behavioral disturbance, largely associated with …
Article scientifique
Model-based clinical utility of pharmacogenetic testing and its potential population impact on the use of essential medicines in Zimbabwe
Introduction: Pharmacogenomic-related adverse drug reactions and treatment failure contribute to global morbidity. Evidence for PGx-guided therapy in sub-Saharan Africa remains …
Article scientifique
Editorial: Use of bioinformatics in pharmacogenetics to optimize drug efficacy
In this editorial, we shed light on this topic by providing an overview of some recent discoveries in the field …
Article scientifique
Evaluation and AI-powered prediction of the efficacy of alirocumab use among patients with cardiovascular disease
Background: Elevated low-density lipoprotein cholesterol (LDL-C) is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Despite statins and ezetimibe, …
Article scientifique
Pharmaceutical wastewater irrigation and metabolite-based environmental pharmacognosy: a perspective on quality and safety risks for medicinal plants
Medicinal plants are increasingly cultivated in agroecosystems irrigated with treated or untreated wastewater, biosolids and contaminated surface water. Pharmaceutical residues …
Article scientifique
Pharmacogenomic variation and chemotherapy-related toxicity profiles in pediatric patients with cancer in Tanzania: a cross-sectional study
Background Chemotherapy-related toxicities remain a major barrier to optimal outcomes in pediatric cancer care in low-resource settings. Genetic variation in …
Article scientifique
Citrus flavonoids mitigate the cisplatin-induced ovarian toxicity via dual modulation of Nrf2/HO-1 pathway and NF-κB axis
Cisplatin (CIS) is an effective chemotherapeutic agent whose clinical use is limited by off-target toxicity, including damage to ovarian granulosa …
Article scientifique
Neuroprotective potential of selenium nanoparticles and/or physical and mental activities against social isolation–induced depression in a rat model: inflammatory, oxidative stress, apoptotic, and neurotransmission modulatory pathways
Background: Social isolation (SI), attributable to modern lifestyles and fast-growing technology, is a leading cause of depression. Selenium nanoparticles (Se-NPs) …
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