397 publication(s) trouvée(s)
Article scientifique
Parasitological efficacy of sulfadoxine-pyrimethamine and amodiaquine for seasonal malaria chemoprevention in Africa
Abstract Seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine plus amodiaquine (SPAQ) protects millions of African children, yet the contribution of each …
Article scientifique
Risk factors for major depressive disorder among adults recruited from hospital settings in Uganda, Kenya, Ethiopia and South Africa
Major depressive disorder (MDD) significantly contributes to the mental health burden in Africa, requiring insights into prevalence and risk factors …
Article scientifique
Evidence of dengue transmission and a diverse Aedes mosquito virome on the Congo’s Angola border
Aedes mosquitoes are widely distributed across the Democratic Republic of Congo (DRC), and are major vectors of dengue (DENV), Zika, …
Article scientifique
A nutrient control on oxygenation dynamics during Earth’s Great Oxidation Episode
Earth's first rise in atmospheric oxygen occurred over a protracted period from ca. 2.43 to 2.06 billion years ago during …
Article scientifique
Mucosal IgA to pre-fusion F protein predicts protection from RSV infection in a high burden setting
Respiratory syncytial virus (RSV) causes over 100,000 annual deaths, predominantly in low- and middle-income countries, yet immunological correlates of protection …
Article scientifique
The roles of pre-season immunity, age, viral shedding, and community exposures in shaping influenza household transmission dynamics
Abstract Our understanding of influenza transmission remains imperfect due to the high prevalence of asymptomatic infections that often go undetected. …
Article scientifique
Patterns of emergence and circulation of West Nile Virus in Algeria
In recent years, many countries have experienced increased outbreaks of vector-borne diseases, such as West Nile virus (WNV). WNV is …
Article scientifique
Phylo-Plex: a phylogenetically informed, low-cost amplicon sequencing platform for deployable high-resolution genomic epidemiology
Genomic pathogen surveillance is a powerful tool for public health and research, but is costly and unachievable in low-resource settings. …
Article scientifique
Targeted next-generation sequencing implementation in Eswatini identifies rifampicin and bedaquiline resistance undetected by routine diagnostic testing
In Eswatini, multidrug-resistant (MDR) Mycobacterium tuberculosis (Mtb) strains harbouring the rifampicin-resistance (RR) rpoB I491F mutation are missed by routine diagnostics, …
Article scientifique
Pharmacokinetics, bactericidal activity and toxicity of short oral regimens for rifampicin-resistant tuberculosis treatment
The exposure and both Mycobacterium tuberculosis clearance rates and toxicity relationships of bedaquiline-pretomanid-linezolid- (BPaL), BPaL-clofazimine (BPaLC) and BPaL-moxifloxacin (BPaLM) for …
Article scientifique
Dimethylsulfoniopropionate metabolism shapes microbial ecology and physiological adaptation during the austral winter in Southern Ocean sea ice and seawater
Dimethylsulfoniopropionate (DMSP) is a highly abundant marine organosulfur compound, with important roles in stress protection and climate-cooling gases production. Polar …
Article scientifique
Rapid development and field evaluation of a portable CRISPR-based assay for Mpox during the 2025 Sierra Leone outbreak
The large 2025 Mpox clade IIb outbreak in Sierra Leone underscores the urgent need for portable, low-cost diagnostics in decentralized …
Article scientifique
Efficacy and durability of immediate versus delayed single-dose HPV vaccination for persistent infection among young women in Kenya: a randomized, blinded, cross-over clinical trial
Evidence is needed for single-dose human papillomavirus (HPV) vaccine efficacy (VE) durability to support vaccination guidelines. In this randomized crossover …
Article scientifique
Quantifying yield losses from Bt resilience among maize cultivars in South Africa
Genetically modified crops have provided economic and social benefits since becoming commercially available. One of the most successful and widely …
Article scientifique
Multiomics characterization of acute child illness and mortality in Africa and South Asia
Childhood illnesses from infectious diseases in low- and middle-income countries contribute substantially to the global under-five mortality. Many hospitalized children …
Article scientifique
Specialised and persistent raw material procurement by humans in the Middle Pleistocene
The selection and acquisition of suitable raw material constitute the first steps in stone tool technology. Previous ethnographical and archaeological …
Article scientifique
Bayesian machine learning enables discovery of risk factors for hepatosplenic multimorbidity related to schistosomiasis
One in 25 deaths worldwide is related to liver disease, and often with multiple hepatosplenic conditions. Yet, little is understood …
Article scientifique
Intermediates of forming transition metal dichalcogenide heterostructures revealed by machine learning simulations
Two-dimensional (2D) transition metal dichalcogenide (TMD) van der Waals heterostructures (vdWHs) hold promise for high-performance electronics, but their large-scale synthesis …
Article scientifique
Why are policies to combat undernutrition not effective in Mozambique?
Despite multiple policies, child undernutrition in Mozambique remains high due to poverty, weak health and food systems, limited community engagement, …
Article scientifique
The gut microbiome and metabolome associate with Schistosoma mansoni infection and cardiovascular disease risk in Uganda
Helminth infections are consistently associated with reduced cardiovascular disease (CVD) risk, yet the biological mechanisms underlying this relationship remain unclear. …
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