397 publication(s) trouvée(s)
Article scientifique
Sensitive near point-of-care detection of asymptomatic and submicroscopic Plasmodium falciparum infections in African endemic countries
Limited diagnostic capacity for detecting asymptomatic malaria infections with low parasite densities hinders elimination efforts in Africa. Here, we adapt …
Article scientifique
Multiplex bead assays enable integrated serological surveillance and reveal cross-pathogen vulnerabilities in Zambezia Province, Mozambique
Multiplex serological assays simultaneously measure antibodies to multiple antigens, furnishing insights into exposure and susceptibility to several pathogens and cross-pathogen …
Article scientifique
One-hour extraction-free loop-mediated isothermal amplification HPV DNA assay for point-of-care testing in Maputo, Mozambique
Human papillomavirus (HPV) is responsible for nearly all cases of cervical cancer. Affordable point-of-care DNA testing is needed for cervical …
Article scientifique
Changes in susceptibility of Plasmodium falciparum to antimalarial drugs in Uganda over time: 2019–2024
Abstract The treatment and control of malaria in Africa is challenged by drug resistance. We characterized ex vivo susceptibilities to …
Article scientifique
Safety and efficacy of 3- and 5-day regimens of levamisole in loiasis: a randomized, placebo-controlled, double-blind clinical trial
Individuals with high Loa loa microfilarial densities (MFD) risk serious adverse events (SAEs) following ivermectin treatment. A single dose of …
Article scientifique
Genes linked to schistosome resistance identified in a genome-wide association study of African snail vectors
Schistosomiasis, a neglected tropical disease, is transmitted by freshwater snails. Interruption of transmission will require novel vector-focused interventions. We performed …
Article scientifique
Potential impact and cost-effectiveness of long-acting injectable lenacapavir plus cabotegravir as HIV treatment in Africa
Although viral suppression is attained for most adults living with diagnosed HIV in East, Central, Southern and West Africa (ECSWA), …
Article scientifique
Context-Seq: CRISPR-Cas9 targeted nanopore sequencing for transmission dynamics of antimicrobial resistance
Abstract Precisely understanding how and to what extent antimicrobial resistance (AMR) is exchanged between animals and humans is needed to …
Article scientifique
Role of the upper airway microbiota in respiratory virus and bacterial pathobiont dynamics in the first year of life
The mechanisms by which respiratory viruses predispose to secondary bacterial infections remain poorly characterized. Using 2,409 nasopharyngeal swabs from 300 …
Article scientifique
Delivering equity in low-carbon multisector infrastructure planning
Many countries worldwide are transitioning from fossil fuel-dependent economies to carbon neutrality, driven by the 2030 agenda for sustainable development …
Article scientifique
HIV status alters immune cell infiltration and activation profile in women with breast cancer
Abstract The breast cancer (BC)-related mortality is higher and the immunity is altered in women living with HIV (WLWH) compared …
Article scientifique
A shared inflammatory signature across severe malaria syndromes manifested by transcriptomic, proteomic and metabolomic analyses
Factors governing the clinical trajectory of Plasmodium falciparum infection remain an important area of investigation. Here we present transcriptomic, proteomic …
Article scientifique
Effect of girls’ education on cancer awareness and screening in a natural experiment in Lesotho
Breast and cervical cancers are important causes of disability and premature death among women in Sub-Saharan Africa. Previous research has …
Article scientifique
An individual-based modelling study estimating the impact of maternity service delivery on health in Malawi
Maternal and perinatal morbidity and mortality remain high in Malawi, partially due to gaps in the coverage and quality of …
Article scientifique
Early-life gut microbiome associates with positive vaccine take and shedding in neonatal schedule of the human neonatal rotavirus vaccine RV3-BB
Rotavirus vaccines are less effective in high mortality regions. A rotavirus vaccine administered at birth may overcome challenges to vaccine …
Article scientifique
Genome-wide association study identifies common variants associated with breast cancer in South African Black women
Abstract Genome-wide association studies (GWAS) have characterized the contribution of common variants to breast cancer (BC) risk in populations of …
Article scientifique
Anomalous δ15N values in the Neoarchean associated with an abundant supply of hydrothermal ammonium
Abstract Unusually high δ 15 N values in the Neoarchean sedimentary record in the time period from 2.8 to 2.6 …
Article scientifique
Leveraging AlphaFold for innovation and sustainable health research in Africa
Without addressing the lack of research infrastructure, funding, and supportive science policies, structural biology capacity-building efforts in Africa will continue …
Article scientifique
Water, sanitation, handwashing, and nutritional interventions can reduce child antibiotic use: evidence from Bangladesh and Kenya
Antibiotics can trigger antimicrobial resistance and microbiome alterations. Reducing pathogen exposure and undernutrition can reduce infections and antibiotic use. We …
Article scientifique
Strontium isoscape of sub-Saharan Africa allows tracing origins of victims of the transatlantic slave trade
Abstract Strontium isotope (87Sr/86Sr) analysis with reference to strontium isotope landscapes (Sr isoscapes) allows reconstructing mobility and migration in archaeology, …