246 publication(s) trouvée(s)
Article scientifique
Revealing the extent of the first wave of the COVID-19 pandemic in Kenya based on serological and PCR-test data
Policymakers in Africa need robust estimates of the current and future spread of SARS-CoV-2. We used national surveillance PCR test, …
Article scientifique
Protocol: the complexity of informal caregiving for Alzheimer's disease and related dementias in rural South Africa
BACKGROUND: With aging, many people develop Alzheimer's disease or related dementias (ADRD) as well as chronic physical health problems. The …
Article scientifique
Evaluating whole HIV-1 genome sequence for estimation of incidence and migration in a rural South African community
Background: South Africa has the largest number of people living with HIV (PLWHIV) in the world, with HIV prevalence and …
Article scientifique
Induction-phase treatment costs for cryptococcal meningitis in high HIV-burden African countries: New opportunities with lower costs
Introduction: Access to and the cost of induction treatment for cryptococcal meningitis (CM) is rapidly changing. The newly-announced price for …
Article scientifique
COVID-19 and older people’s wellbeing in northern KwaZulu-Natal – the importance of relationships
Background: The COVID-19 pandemic and the non-pharmacological prevention methods have affected the wellbeing of older people. In this paper we …
Article scientifique
The influence of pneumococcal conjugate vaccine-13 on nasal colonisation in a controlled human infection model of pneumococcal carriage in Malawi: a double-blinded randomised controlled trial protocol
Streptococcus pneumoniae is the leading cause of morbidity and mortality due to community acquired pneumonia, bacterial meningitis and bacteraemia worldwide. …
Article scientifique
Pandemic preparedness and responsiveness of research review committees: lessons from review of COVID-19 protocols at KEMRI Wellcome Trust Research Programme in Kenya
Background : The scale of the COVID-19 pandemic and novelty of SARS-CoV-2 presented unprecedented challenges in the review of COVID-19 …
Article scientifique
“We threw away the stones”: a mixed method evaluation of a simple cookstove intervention in Malawi
Background: Air pollution exposure is responsible for a substantial burden of respiratory disease globally. Household air pollution from cooking using …
Article scientifique
Protocol: Mapping social networks, social influence and sexual health among youth in rural KwaZulu-Natal, the Sixhumene cohort study
Background : Sexual behaviour and sexually transmitted infections are strongly affected by social connections, and interventions are often adapted more …
Article scientifique
The safety and immunogenicity of a combined pertussis containing vaccine Tdap for HIV infected pregnant women and their newborns (WoMANPOWER) – A study protocol for a randomized clinical trial
Background: Globally there are an estimated 24.1 million cases and 160,700 deaths from pertussis annually in children under five years. …
Article scientifique
A multi-parameter diagnostic clinical decision tree for the rapid diagnosis of tuberculosis in HIV-positive patients presenting to an emergency centre
Background: Early diagnosis is essential to reduce the morbidity and mortality of HIV-associated tuberculosis. We developed a multi-parameter clinical decision …
Article scientifique
Sociodemographic characteristics of community eye screening participants: protocol for cross-sectional equity analyses in Botswana, Kenya, and Nepal
Background: Attendance rates for eye clinics are low across low- and middle-income countries (LMICs) and exhibit marked sociodemographic inequalities. We …
Article scientifique
Detection of pathogens associated with early-onset neonatal sepsis in cord blood at birth using quantitative PCR
Background: Early onset neonatal sepsis (EONS) typically begins prior to, during or soon after birth and may be rapidly fatal. …
Article scientifique
A qualitative study exploring health workers and patient caregivers’ hand hygiene practices in a neonatal unit in Blantyre, Malawi, implications for controlling outbreaks of drug resistant infections
Background: Neonatal sepsis is responsible for a considerable burden of morbidity and mortality in sub-Saharan African countries. Outcomes from neonatal …
Article scientifique
Validation and clinical application of a method to quantify efavirenz in cervicovaginal secretions from flocked swabs using liquid chromatography tandem mass spectrometry
Background : A liquid chromatography tandem mass spectrometry method to quantify drugs in dried cervicovaginal secretions from flocked swabs was …
Article scientifique
Incidence of invasive non-typhoidal Salmonella in Blantyre, Malawi between January 2011-December 2019
Background: The Malawi-Liverpool Wellcome Trust Clinical Research Programme (MLW) has undertaken sentinel surveillance of bloodstream infection and meningitis at Queen …
Article scientifique
Missed nursing care in acute care hospital settings in low-middle income countries: a systematic review protocol
Background: Missed nursing care (care left undone or task incompletion) is viewed as an important early predictor of adverse patient …
Article scientifique
Knowledge, attitudes and practices relating to antibiotic use and resistance among prescribers from public primary healthcare facilities in Harare, Zimbabwe
Background Overuse of antibiotics is one of the main drivers for antimicrobial resistance (AMR). Globally, most antibiotics are prescribed in …
Article scientifique
Efficiency of transplacental transfer of respiratory syncytial virus (RSV) specific antibodies among pregnant women in Kenya
Background: Maternal immunisation to boost respiratory syncytial virus (RSV) antibodies in pregnant women, is a strategy being considered to enhance …
Article scientifique
Maintaining laboratory quality assurance and safety in a pandemic: Experiences from the KEMRI-Wellcome Trust Research Programme laboratory’s COVID-19 response
Laboratory diagnosis plays a critical role in the containment of a pandemic. Strong laboratory quality management systems (QMS) are essential …
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