210 publication(s) trouvée(s)
Article scientifique
Targeted Amplicon deep sequencing of ama1 and mdr1 to track within-host P. falciparum diversity throughout treatment in a clinical drug trial
Antimalarial therapeutic efficacy studies are routinely conducted in malaria-endemic countries to assess the effectiveness of antimalarial treatment strategies. Targeted amplicon …
Article scientifique
A PowerPack of SuperScientists: An innovative concept by African scientists to address gender bias and inequity in science
Underrepresentation of women in scientific leadership is a global problem. To understand and counter narratives that limit gender equity in …
Article scientifique
Health care users’ acceptance of broad consent for storage of biological materials and associated data for research purposes in Uganda
Background: Implementation of appropriate informed consent has become a cornerstone for the use of biological materials and data from clinical …
Article scientifique
An optimization of four SARS-CoV-2 qRT-PCR assays in a Kenyan laboratory to support the national COVID-19 rapid response teams
Background: The COVID-19 pandemic relies on real-time polymerase chain reaction (qRT-PCR) for the detection of Severe Acute Respiratory Syndrome Coronavirus …
Article scientifique
Neurocognitive outcomes of tuberculous meningitis in a primarily HIV-positive Ugandan cohort
Background: The toll of tuberculous meningitis (TBM) in both mortality and disability is considerable, but advancements in rehabilitation have the …
Article scientifique
TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming phase 1 (safety, tolerability, pharmacokinetics and pharmacodynamics in healthy Kenyan adults)
Background: Snakebites affect over 5 million people each year, and over 100,000 per year die as a result. The only …
Article scientifique
Promotion of data sharing needs more than an emergency: An analysis of trends across clinical trials registered on the International Clinical Trials Registry Platform
BACKGROUND: A growing body of evidence shows that sharing health research data with other researchers for secondary analyses can contribute …
Article scientifique
“My life is not going to be the same, my health is going to improve”: a cross-sectional qualitative study of patients’ experiences of living with chronic respiratory symptoms and their views on a proposed pulmonary rehabilitation program at Queen Elizabeth Central Hospital, Blantyre, Malawi
Background: Malawi’s population has a substantial burden of chronic respiratory symptoms. Elsewhere, patients with these symptoms have benefited from pulmonary …
Article scientifique
A network of empirical ethics teams embedded in research programmes across multiple sites: opportunities and challenges in contributing to COVID-19 research and responses
Covid-19 continues to teach the global community important lessons about preparedness for research and effective action to respond to emerging …
Article scientifique
“An increase in COVID-19 patients would be overwhelming”: A qualitative description of healthcare workers’ experiences during the first wave of COVID-19 (March 2020 to October 2020) at Malawi’s largest referral hospital.
Background COVID-19 is currently a global health threat. Healthcare workers are on the front-line of the COVID-19 outbreak response and …
Article scientifique
A comparison of the population pharmacokinetics of rifampicin, isoniazid and pyrazinamide between hospitalized and non-hospitalized tuberculosis patients with or without HIV
Background: Early mortality among hospitalized HIV-associated tuberculosis (TB/HIV) patients is high despite treatment. The pharmacokinetics of rifampicin, isoniazid, and pyrazinamide …
Article scientifique
Putting youth at the centre: co-design of a community-based intervention to improve HIV outcomes among youth in Zimbabwe
Abstract Background Youth have disproportionately poor HIV outcomes. We aimed to co-design a community-based intervention with youth to improve HIV …
Article scientifique
Drivers of Resistance in Uganda and Malawi (DRUM): a protocol for the evaluation of One-Health drivers of Extended Spectrum Beta Lactamase (ESBL) resistance in Low-Middle Income Countries (LMICs)
In sub-Saharan Africa (sSA), there is high morbidity and mortality from severe bacterial infection and this is compounded by antimicrobial …
Article scientifique
Individual-level variations in malaria susceptibility and acquisition of clinical protection
After decades of research, our understanding of when and why individuals infected with Plasmodium falciparum develop clinical malaria is still …
Article scientifique
Epidemiology of COVID-19 infections on routine polymerase chain reaction (PCR) and serology testing in Coastal Kenya
Background: There are limited studies in Africa describing the epidemiology, clinical characteristics and serostatus of individuals tested for severe acute …
Article scientifique
The impact of community-based integrated HIV and sexual and reproductive health services for youth on population-level HIV viral load and sexually transmitted infections in Zimbabwe: protocol for the CHIEDZA cluster-randomised trial
Background: Youth have poorer HIV-related outcomes when compared to other age-groups. We describe the protocol for a cluster randomised trial …
Article scientifique
Cost-effectiveness of cryptococcal antigen screening at CD4 counts of 101–200 cells/µL in Botswana
Background: Cryptococcal antigen (CrAg) screening in individuals with advanced HIV reduces cryptococcal meningitis (CM) cases and deaths. The World Health …
Article scientifique
10-year longitudinal study of malaria in children: Insights into acquisition and maintenance of naturally acquired immunity
Background: Studies of long-term malaria cohorts have provided essential insights into how Plasmodium falciparum interacts with humans, and influences the …
Article scientifique
Missed nursing care in acute care hospital settings in low-middle income countries: a systematic review protocol
Background: Missed nursing care (care left undone or task incompletion) is viewed as an important early predictor of adverse patient …
Article scientifique
Using Machine Learning Methods Incorporating Individual Reader Annotations to Classify Paediatric Chest Radiographs in Epidemiological Studies
Introduction : Epidemiological studies that involve interpretation of chest radiographs (CXRs) suffer from inter-reader and intra-reader variability. Inter-reader and intra-reader …