210 publication(s) trouvée(s)
Article scientifique
Effects of iron intake on neurobehavioural outcomes in African children: a systematic review and meta-analysis of randomised controlled trials
Background: Iron deficiency and developmental delay are common in African children. While experimental studies indicate an important role of iron …
Article scientifique
Case Report: A gambling-related suicide in rural Malawi
Background As in many other countries across sub-Saharan Africa, Malawi's commercial gambling sector has grown considerably in recent years. Driven …
Article scientifique
Rates of refusal of clinical autopsies among HIV-positive decedents and an overview of autopsies in Uganda
Background: Human immunodeficiency virus (HIV)-related mortality remains high in sub-Saharan Africa. Clinical autopsies can provide invaluable information to help ascertain …
Article scientifique
The hidden financial burden of healthcare: a systematic literature review of informal payments in Sub-Saharan Africa
Background: Informal payments limit equitable access to healthcare. Despite being a common phenomenon, there is a need for an in-depth …
Article scientifique
Short-term metabolic resistance inductive effect of different agrochemical groups on Anopheles gambiae mosquitoes
Background: In order to assess the impact of the different groups of agricultural pesticides used in Côte d'Ivoire on the …
Article scientifique
Profiles of inflammatory markers and their association with cardiometabolic parameters in rural and urban Uganda
Background: Inflammation may be one of the pathways explaining differences in cardiometabolic risk between urban and rural residents. We investigated …
Article scientifique
Circulating microparticles are increased amongst people presenting with HIV and advanced immune suppression in Malawi and correlate closely with arterial stiffness: a nested case control study
Background: We aimed to investigate whether circulating microparticle (CMPs) subsets were raised amongst people presenting with human immunodeficiency virus (HIV) …
Article scientifique
The Gambia National Eye Health Survey 2019: survey protocol
Two national surveys of vision impairment and blindness were undertaken in The Gambia in 1986 and 1996. These provided data …
Article scientifique
Children’s Oxygen Administration Strategies And Nutrition Trial (COAST-Nutrition): a protocol for a phase II randomised controlled trial
Background: To prevent poor long-term outcomes (deaths and readmissions) the integrated global action plan for pneumonia and diarrhoea recommends under …
Article scientifique
“At first, I was very afraid”—a qualitative description of participants’ views and experiences in the first Human Infection Study in Malawi
Background: Human infection studies (HIS) involve deliberately infecting healthy volunteers with a pathogen in a controlled environment to understand infection …
Article scientifique
Children against antibiotics misuse and antimicrobial resistance: assessing effectiveness of storytelling and picture drawing as public engagement approaches
Background : Interventions delivered in schools have been found to be effective in improving knowledge of antibiotics and antimicrobial resistance …
Article scientifique
Validation and clinical application of a method to quantify efavirenz in cervicovaginal secretions from flocked swabs using liquid chromatography tandem mass spectrometry
Background : A liquid chromatography tandem mass spectrometry method to quantify drugs in dried cervicovaginal secretions from flocked swabs was …
Article scientifique
Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the ‑α3.7I form of α-thalassaemia using genome-wide microarray data
Background: The -α 3.7I -thalassaemia deletion is very common throughout Africa because it protects against malaria. When undertaking studies to …
Article scientifique
Whole genome sequencing of two human rhinovirus A types (A101 and A15) detected in Kenya, 2016-2018
Background: Virus genome sequencing is increasingly utilized in epidemiological surveillance. Genomic data allows comprehensive evaluation of underlying viral diversity and …
Article scientifique
Engagement of ethics and regulatory authorities on human infection studies: Proceedings of an engagement workshop in Zambia
Human infection studies (HIS) have generally been used as a tool in the pathway for vaccine development in high income …
Article scientifique
Individual-level variations in malaria susceptibility and acquisition of clinical protection
After decades of research, our understanding of when and why individuals infected with Plasmodium falciparum develop clinical malaria is still …
Article scientifique
The influence of pneumococcal conjugate vaccine-13 on nasal colonisation in a controlled human infection model of pneumococcal carriage in Malawi: a double-blinded randomised controlled trial protocol
Streptococcus pneumoniae is the leading cause of morbidity and mortality due to community acquired pneumonia, bacterial meningitis and bacteraemia worldwide. …
Article scientifique
Protocol for a prospective cohort study of open tibia fractures in Malawi with a nested implementation of open fracture guidelines
Background : Road traffic injury (RTI) is the largest cause of death amongst 15–39-year-old people worldwide, and the burden of …
Article scientifique
Exposure to parasitic infections determines features and phenotypes of active convulsive epilepsy in Africa
Background : Epilepsy affects 70 million people worldwide, 80% of whom are in low-and-middle income countries (LMICs). Infections of the …
Article scientifique
Impact of sublethal pyrethroid exposure on resistant Anopheles gambiae mosquitoes’ fitness
Background : There is increasing evidence of insecticide resistance spreading among wild mosquito populations, which is widely believed to compromise …