210 publication(s) trouvée(s)
Article scientifique
Performance of molecular methods for the detection of Salmonella in human stool specimens
Background: The relationship between asymptomatic Salmonella exposure within the gastrointestinal tract and Salmonella bacteraemia is poorly understood, in part due …
Article scientifique
Impact of Plasmodium falciparum small-sized extracellular vesicles on host peripheral blood mononuclear cells
Background: Exagerated immune activation has a key role in the pathogenesis of malaria . During blood-stage infection, Plasmodium falciparum can …
Article scientifique
Ethical, Regulatory and Market related aspects of Deploying Triple Artemisinin-Based Combination Therapies for Malaria treatment in Africa: A study protocol.
Introduction: According to the World Malaria Report 2019, Africa accounts for 94% of the global malaria deaths. While malaria prevalence …
Article scientifique
Derivation and internal validation of a data-driven prediction model to guide frontline health workers in triaging children under-five in Nairobi, Kenya
Background: Many hospitalized children in developing countries die from infectious diseases. Early recognition of those who are critically ill coupled …
Article scientifique
Assessing the progress and gaps in strategic health purchasing in Kenya
Background: Kenya has committed to achieve universal health coverage (UHC) and prioritised purchasing reforms. Existing evidence indicates that purchasing can …
Article scientifique
Prevalence of asymptomatic P. falciparum gametocyte carriage among school children in Mbita, Western Kenya and assessment of the association between gametocyte density, multiplicity of infection and mosquito infection prevalence.
Background: Asymptomatic Plasmodium falciparum gametocyte carriers are reservoirs for sustaining transmission in malaria endemic regions. Gametocyte presence in the host …
Article scientifique
Does recall time matter in verbal autopsies? Evidence from urban informal settlements in Nairobi, Kenya
Background: To assign a cause of death to non-medically certified deaths, verbal autopsies (VAs) are widely used to determine the …
Article scientifique
Perspectives of different stakeholders on data use and management in public health emergencies in sub-Saharan Africa: a meeting report
During public health emergencies (PHEs), data are collected and generated from a variety of activities and sources, including but not …
Article scientifique
Knowledge, attitudes and practices relating to antibiotic use and resistance among prescribers from public primary healthcare facilities in Harare, Zimbabwe
Background Overuse of antibiotics is one of the main drivers for antimicrobial resistance (AMR). Globally, most antibiotics are prescribed in …
Article scientifique
Systemic inflammation is negatively associated with early post discharge growth following acute illness among severely malnourished children - a pilot study
Background: Rapid growth should occur among children with severe malnutrition (SM) with medical and nutritional management. Systemic inflammation (SI) is …
Article scientifique
The effect of sertraline on depression and associations with persistent depression in survivors of HIV-related cryptococcal meningitis
Background : Depression is a risk factor for worse outcomes in persons living with HIV/AIDS and has a prevalence more …
Article scientifique
Co-prevalent infections in adults with HIV-associated cryptococcal meningitis are associated with an increased risk of death: a nested analysis of the Advancing Cryptococcal meningitis Treatment for Africa (ACTA) cohort
Background: HIV-associated cryptococcal meningitis accounts for 15% of AIDS related deaths globally. In sub-Saharan Africa, acute mortality ranges from 24% …
Article scientifique
Z Factor: Drama as a tool to tackle mental health stigma: study design and protocol for community and public engagement in rural Zimbabwe
Background: Mental health is slowly gaining global significance as a key health issue, yet the stigma attached to psychosis is …
Article scientifique
AntiRetroviral Therapy In Second-line: investigating Tenofovir-lamivudine-dolutegravir (ARTIST): protocol for a randomised controlled trial
Background: Dolutegravir has superior efficacy and tolerability than lopinavir-ritonavir in second-line antiretroviral therapy after failure of a first-line non-nucleoside reverse …
Article scientifique
A reproducible picture of open access health facility data in Africa and R tools to support improvement
Background: Open data on the locations and services provided by health facilities have, in some countries, allowed the development of …
Article scientifique
Before the whistle blows: developing new paradigms in tuberculosis screening to maximise benefit and minimise harm
We summarise recent emerging evidence around tuberculosis (TB) transmission and its role in tuberculosis epidemiology, and in novel TB screening …
Article scientifique
Always leave the audience wanting more: An entertaining approach to stimulate engagement with health research among publics in coastal Kenya through ‘Magnet Theatre’
Background: Magnet Theatre (MT), a form of participatory community theatre, is one of several public engagement approaches used to facilitate …
Article scientifique
Recommendations for the development of Egyptian human biobanking ethical guidelines
Background: The development of biobanks is associated with the emergence of new ethical challenges. In Egypt, several biobanks have been …
Article scientifique
The diagnosis of tuberculous meningitis in adults and adolescents: protocol for a systematic review and individual patient data meta-analysis to inform a multivariable prediction model
Background: Tuberculous meningitis (TBM) is the most lethal and disabling form of tuberculosis. Delayed diagnosis and treatment, which is a …
Article scientifique
Mortality during and following hospital admission among school-aged children: a cohort study
Background: Far less is known about the reasons for hospitalization or mortality during and after hospitalization among school-aged children than …