210 publication(s) trouvée(s)
Article scientifique
Standard versus double dose dolutegravir in patients with HIV-associated tuberculosis: a phase 2 non-comparative randomised controlled (RADIANT-TB) trial
Dolutegravir, a second-generation integrase strand transfer inhibitor (InSTI), is replacing efavirenz as first-line antiretroviral therapy (ART) in low middle-income countries …
Article scientifique
Derivation and internal validation of a data-driven prediction model to guide frontline health workers in triaging children under-five in Nairobi, Kenya
Background: Many hospitalized children in developing countries die from infectious diseases. Early recognition of those who are critically ill coupled …
Article scientifique
Self-reported disability in rural Malawi: prevalence, incidence, and relationship to chronic conditions
Background: Disability is a complex concept involving physical impairment, activity limitation, and participation restriction. The Washington Group developed a set …
Article scientifique
Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the ‑α3.7I form of α-thalassaemia using genome-wide microarray data
Background: The -α 3.7I -thalassaemia deletion is very common throughout Africa because it protects against malaria. When undertaking studies to …
Article scientifique
Analysis of cancer diagnoses from 2015-2019 within Machakos County, Kenya, support establishment of Cancer Centre in 2019 likely changing referral patterns
Background: In Kenya, cancer is an increasing public health challenge, with an estimated 48,000 new cancer cases and over 33,000 …
Article scientifique
Electronic data capture for large scale typhoid surveillance, household contact tracing, and health utilisation survey: Strategic Typhoid Alliance across Africa and Asia
Electronic data capture systems (EDCs) have the potential to achieve efficiency and quality in collection of multisite data. We quantify …
Article scientifique
Programme theory and linked intervention strategy for large-scale change to improve hospital care in a low and middle-income country - A Study Pre-Protocol
In low and middle-income countries (LMIC) general hospitals are important for delivering some key acute care services. Neonatal care is …
Article scientifique
Plasma calprotectin as a biomarker of mortality at antiretroviral treatment initiation in advanced HIV – pilot study
Background: In advanced HIV, significant mortality occurs soon after starting antiretroviral treatment (ART) in low- and middle-incomes countries. Calprotectin is …
Éditorial
The ethics of data sharing and biobanking in health research
The importance of data sharing and biobanking are increasingly being recognised in global health research. Such practices are perceived to …
Article scientifique
Screening of cardiovascular risk assessment accuracy of anthropometric indices in Indian children and adolescents
Background : Body mass index (BMI) is the most popular anthropometric marker to define obesity and cardiometabolic risk. BMI is …
Article scientifique
Cost-effectiveness and public health impact of RTS,S/AS01E malaria vaccine in Malawi, using a Markov static model
Background: The RTS,S/AS01 E malaria vaccine is being assessed in Malawi, Ghana and Kenya as part of a large-scale pilot …
Article scientifique
Multiple insecticide resistance and Plasmodium infection in the principal malaria vectors Anopheles funestus and Anopheles gambiae in a forested locality close to the Yaoundé airport, Cameroon
Background: Reducing the burden of malaria requires better understanding of vector populations, particularly in forested regions where the incidence remains …
Article scientifique
Engagement and social acceptance in genome editing for human benefit: Reflections on research and practice in a global context
While there are both practical and ethical reasons for public engagement in science and innovation, real-world detailed examples of engagement …
Article scientifique
Mortality during and following hospital admission among school-aged children: a cohort study
Background: Far less is known about the reasons for hospitalization or mortality during and after hospitalization among school-aged children than …
Article scientifique
Prevalence of asymptomatic P. falciparum gametocyte carriage in schoolchildren and assessment of the association between gametocyte density, multiplicity of infection and mosquito infection prevalence
Background: Malaria is a major public health threat in sub-Saharan Africa. Asymptomatic Plasmodium falciparum gametocyte carriers are potential infectious reservoirs …
Article scientifique
Bimodal distribution and set point HBV DNA viral loads in chronic infection: retrospective analysis of cohorts from the UK and South Africa
Hepatitis B virus (HBV) viral load (VL) is used as a biomarker to assess risk of disease progression, and to …
Article scientifique
Systemic inflammation is negatively associated with early post discharge growth following acute illness among severely malnourished children - a pilot study
Background: Rapid growth should occur among children with severe malnutrition (SM) when medically and nutritionally treated. Systemic inflammation (SI) is …
Article scientifique
Performance of molecular methods for the detection of Salmonella in human stool specimens
Background: The relationship between asymptomatic Salmonella exposure within the gastrointestinal tract and Salmonella bacteraemia is poorly understood, in part due …
Article scientifique
Cost and cost-effectiveness analysis of treatment for child undernutrition in low- and middle-income countries: A systematic review
Background : Undernutrition remains highly prevalent in low- and middle-income countries, with sub-Saharan Africa and Southern Asia accounting for majority …
Article scientifique
Does recall time matter in verbal autopsies? Evidence from urban informal settlements in Nairobi, Kenya
Background: To assign a cause of death to non-medically certified deaths, verbal autopsies (VAs) are widely used to determine the …