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Publications
7361 publication(s) trouvée(s)
Article scientifique
Polyphenols: Chemoprevention and therapeutic potentials in hematological malignancies
Polyphenols are one of the largest plant-derived natural product and they play an important role in plants' defense as well …
Article scientifique
Prevalence, antibiotic profile, virulence determinants, ESBLs, and non-β-lactam encoding genes of MDR Proteus spp. isolated from infected dogs
This study investigated the prevalence, antibiogram, virulence, extended-spectrum β-lactamases (ESBLs), and non-β-lactam encoding genes of Proteus species isolated from infected …
Article scientifique
Insights on attenuating autophagy cellular and molecular pathways versus methotrexate-induced toxicity via liposomal turmeric therapy
BACKGROUND: Methotrexate (MX), a competitive inhibitor of dihydrofolate reductase, can inhibit DNA and RNA production and is a powerful anticancer …
Article scientifique
Expression profile of serum LncRNA THRIL and MiR-125b in inflammatory bowel disease
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract. We aimed to investigate, for the …
Article scientifique
Implication of extrinsic and intrinsic apoptotic pathways in the targeted therapy of hepatocellular carcinoma using aptamer-labeled viramidine nanoparticles
Abstract Hepatocellular carcinoma (HCC) is a global health problem with regional differences in epidemiological statistics. Co-assembling the drug nanoparticles and …
Article scientifique
Annona muricata L. peel extract inhibits carbohydrate metabolizing enzymes and reduces pancreatic β-cells, inflammation, and apoptosis via upregulation of PI3K/AKT genes
BACKGROUND AND OBJECTIVE: Annona muricata L. peel has been recognized for many ethnobotanical uses, including diabetes management. However, limited detailed …
Article scientifique
The dual role of the hexosamine biosynthetic pathway in cardiac physiology and pathophysiology
The heart is a highly metabolic organ with extensive energy demands and hence relies on numerous fuel substrates including fatty …
Article scientifique
Intestinal microbiome–rheumatoid arthritis crosstalk: The therapeutic role of probiotics
Rheumatoid arthritis (RA) is a common systemic autoimmune disease with a global health importance. It is characterized by long-term complications, …
Article scientifique
Oculocutaneous albinism in southern Africa: Historical background, genetic, clinical and psychosocial issues
Albinism is an inherited condition associated with significant depigmentation of the skin, hair and eyes. It occurs in every population …
Article scientifique
Synthesis and anticancer activity of new benzensulfonamides incorporating s-triazines as cyclic linkers for inhibition of carbonic anhydrase IX
Abstract Limited presence of hCA IX in normal physiological tissues and their overexpression only in solid hypoxic tumors made this …
Article scientifique
Insights on the performance of phenotypic tests versus genotypic tests for the detection of carbapenemase-producing Gram-negative bacilli in resource-limited settings
Abstract Background: Carbapenemase-producing Gram-negative (CPGN) bacteria impose life-threatening infections with limited treatment options. Rigor and rapid detection of CPGN-associated infections …
Article scientifique
Advancing mRNA technologies for therapies and vaccines: An African context
Synthetic mRNA technologies represent a versatile platform that can be used to develop advanced drug products. The remarkable speed with …
Article scientifique
Targeting hepatic sulfane sulfur/hydrogen sulfide signaling pathway with α-lipoic acid to prevent diabetes-induced liver injury via upregulating hepatic CSE/3-MST expression
BACKGROUND: Diabetes-induced liver injury is a complication of diabetes mellitus of which there are no approved drugs for effective treatment …
Article scientifique
Prevalence of extended-spectrum β-lactamases, AmpC, and carbapenemases in Proteus mirabilis clinical isolates
Abstract Background Proteus mirabilisis an opportunistic pathogen, causing a variety of community-acquired and nosocomial illnesses. It poses a potential threat …
Article scientifique
Epidemiology, pathology, prevention, and control strategies of inclusion body hepatitis and hepatitis-hydropericardium syndrome in poultry: A comprehensive review
Infection with fowl adenoviruses (FAdVs) can result in a number of syndromes in the production of chicken, including inclusion body …
Article scientifique
Genome-wide analysis of polyamine biosynthesis genes in wheat reveals gene expression specificity and involvement of STRE and MYB-elements in regulating polyamines under drought
BACKGROUND: Polyamines (PAs) are considered promising biostimulants that have diverse key roles during growth and stress responses in plants. Nevertheless, …
Article scientifique
Notch-associated lncRNAs profiling circuiting epigenetic modification in colorectal cancer
BACKGROUND: Colorectal cancer (CRC) is one of the most prevalent digestive cancers, ranking the 2nd cause of cancer-related fatality worldwide. …
Article scientifique
Zinc oxide nanoparticles reduce biofilm formation, synergize antibiotics action and attenuate Staphylococcus aureus virulence in host; an important message to clinicians
BACKGROUND: Biofilm-related infections are difficult to be treated because of higher resistance to antimicrobial agents. Current study aims to characterize …
Article scientifique
Developing regenerated rice lines by the anther culture method
When developing a variety, along with the classical breeding methods, there are increasingly being used bio-technological and molecular genetic methods. …
Article scientifique
The Inhibitory Effect of Haloxylon, Cichorium spp and Capparis spp on Cercospora leaf spot disease on sugar beet in vitro and vivo
Abstract Sugar beet (Beta vulgaris L.) is one of the most important sugar crops in the world, which considered the …