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7357 publication(s) trouvée(s)
Article scientifique
Enhancing explainable SARS-CoV-2 vaccine development leveraging bee colony optimised Bi-LSTM, Bi-GRU models and bioinformatic analysis
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a single-stranded RNA virus that caused the outbreak of the coronavirus …
Article scientifique
Design, synthesis and in vitro anticancer activity of some new lomefloxacin derivatives
Abstract Our main goal was to design and synthesize novel lomefloxacin derivatives that inhibit the topoisomerase II enzyme, leading to …
Article scientifique
Spatiotemporal dynamics of cholera hotspots in the Democratic Republic of the Congo from 1973 to 2022
BACKGROUND: Since the early 1970s, cholera outbreaks have been a major public health burden in the Democratic Republic of Congo …
Article scientifique
Safety and efficacy of trofinetide in Rett syndrome: a systematic review and meta-analysis of randomized controlled trials
INTRODUCTION: Rett syndrome is a rare genetic neurodevelopmental disorder that predominantly impacts females. It presents with loss of acquired skills, …
Article scientifique
In vitro and in silico studies of enterobactin-inspired Ciprofloxacin and Fosfomycin first generation conjugates on the antibiotic resistant E. coli OQ866153
BACKGROUND: The emergence of antimicrobial resistance in bacterial pathogens is a growing concern worldwide due to its impact on the …
Article scientifique
Analysis of disease characteristics of a large patient cohort with congenital generalized lipodystrophy from the Middle East and North Africa
BACKGROUND: Congenital generalized lipodystrophy (CGL) is a rare inherited disease characterized by a near-total absence of adipose tissue and is …
Article scientifique
Tailoring IPM plans to fight a cloaked pest: helping smallholder farmers combat the sweetpotato weevil in sub-Saharan Africa
Abstract Africa accounts for a significant portion of the world’s sweetpotato production where it is widely grown as a staple …
Article scientifique
Nutritional composition, phytochemicals, and antioxidant activities of Abies marocana Trab. needles
Introduction Finding natural sources of bioactive compounds is turning into a cutting- edge task for the scientific community and industry …
Article scientifique
Genome mining of Escherichia coli WG5D from drinking water source: unraveling antibiotic resistance genes, virulence factors, and pathogenicity
BACKGROUND: Escherichia coli, a ubiquitous inhabitant of the gut microbiota, has been recognized as an indicator of fecal contamination and …
Article scientifique
Optimizing combination therapy in prostate cancer: mechanistic insights into the synergistic effects of Paclitaxel and Sulforaphane-induced apoptosis
BACKGROUND: Combination therapies in cancer treatment have demonstrated synergistic or additive outcomes while also reducing the development of drug resistance …
Article scientifique
Decoding the secrets of longevity: unraveling nutraceutical and miRNA-Mediated aging pathways and therapeutic strategies
MicroRNAs (miRNAs) are short RNA molecules that are not involved in coding for proteins. They have a significant function in …
Article scientifique
Laser-induced changes in the gene expression, growth and development of Gladiolus grandiflorus cv. “White Prosperity”
Abstract Corms of Gladiolus grandiflorus cv. “White Prosperity” was irradiated via red laser at wavelength 635 nm. Various morphological, flowering, …
Article scientifique
Gut dysbiosis is linked to metabolic syndrome in obese Egyptian women: potential treatment by probiotics and high fiber diets regimen
Metabolic syndrome (MetS) is defined as a cluster of glucose intolerance, hypertension, dyslipidemia, and central obesity with insulin resistance. The …
Article scientifique
Characterisation of colistin resistance in Gram-negative microbiota of pregnant women and neonates in Nigeria
A mobile colistin resistance gene mcr was first reported in 2016 in China and has since been found with increasing …
Article scientifique
Untargeted metabolomic profiling reveals molecular signatures associated with type 2 diabetes in Nigerians
BACKGROUND: Type 2 diabetes (T2D) has reached epidemic proportions globally, including in Africa. However, molecular studies to understand the pathophysiology …
Article scientifique
Bridging the gap between omics research and dental practice
AIM: The burgeoning field of omics research has witnessed exponential growth in both medicine and dentistry. However, despite more than …
Article scientifique
Global and regional prevalence of Cronobacter sakazakii in powdered milk and flour
Cronobacter sakazakii (Cz) infections linked with powdered milk/flour (PMF) are on the increase in recent times. The current study aimed …
Article scientifique
Comprehensive study on in vitro propagation of some imported peach rootstocks: in vitro explant surface sterilization and bud proliferation
The present study was conducted in the Laboratory of Tissue Culture, Horticulture Department, Faculty of Agriculture, Damietta University, Egypt. The …
Article scientifique
Colonisation of hospital surfaces from low- and middle-income countries by extended spectrum β-lactamase- and carbapenemase-producing bacteria
Abstract Hospital surfaces can harbour bacterial pathogens, which may disseminate and cause nosocomial infections, contributing towards mortality in low- and …
Article scientifique
Generalizability of machine learning in predicting antimicrobial resistance in E. coli: a multi-country case study in Africa
BACKGROUND: Antimicrobial resistance (AMR) remains a significant global health threat particularly impacting low- and middle-income countries (LMICs). These regions often …