7361
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Biologie synthétique
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Publications
7361 publication(s) trouvée(s)
Article scientifique
Design and synthesis of novel cytotoxic fluoroquinolone analogs through topoisomerase inhibition, cell cycle arrest, and apoptosis
Abstract To exploit the advantageous properties of approved drugs to hasten anticancer drug discovery, we designed and synthesized a series …
Article scientifique
Cholera outbreak in some communities in North-East Nigeria, 2019: an unmatched case–control study
BACKGROUND: Cholera, a diarrheal disease caused by the bacterium Vibrio cholerae, transmitted through fecal contamination of water or food remains …
Article scientifique
Surveillance of Vibrio parahaemolyticus pathogens recovered from ready-to-eat foods
Abstract This study examined the occurrence of V. parahaemolyticus from ready-to-eat (RTE) food in Delta State, Nigeria. It also characterized …
Article scientifique
How to succeed in implementing community-based breeding programs: Lessons from the field in Eastern and Southern Africa
Breeding programs involving either centralized nucleus schemes and/or importation of exotic germplasm for crossbreeding were not successful and sustainable in …
Article scientifique
Anticancer derivative of the natural alkaloid, theobromine, inhibiting EGFR protein: Computer-aided drug discovery approach
A new semisynthetic derivative of the natural alkaloid, theobromine, has been designed as a lead antiangiogenic compound targeting the EGFR …
Article scientifique
Multidrug-resistant extended spectrum β-lactamase (ESBL)-producing Escherichia coli from farm produce and agricultural environments in Edo State, Nigeria
Antimicrobial resistance (AMR) is a major public health concern, especially the extended-spectrum β-lactamase-producing (ESBL) Escherichia coli bacteria are emerging as …
Article scientifique
Bioactive Azadirachta indica and Melia azedarach leaves extracts with anti-SARS-CoV-2 and antibacterial activities
The leaves of Azadirachta indica L. and Melia azedarach L., belonging to Meliaceae family, have been shown to have medicinal …
Article scientifique
Ceftazidime-Avibactam plus aztreonam synergistic combination tested against carbapenem-resistant Enterobacterales characterized phenotypically and genotypically: a glimmer of hope
BACKGROUND: Carbapenemase-producing Enterobacterales (CPE) show rapid global dissemination and pose a significant therapeutic challenge. This study aimed to characterize carbapenemase-producing …
Article scientifique
Irinotecan-gut microbiota interactions and the capability of probiotics to mitigate Irinotecan-associated toxicity
BACKGROUND: Irinotecan is a chemotherapeutic agent used to treat a variety of tumors, including colorectal cancer (CRC). In the intestine, …
Rapport d'évaluation
Author response: Mitochondrial redox adaptations enable alternative aspartate synthesis in SDH-deficient cells
The oxidative tricarboxylic acid (TCA) cycle is a central mitochondrial pathway integrating catabolic conversions of NAD +to NADH and anabolic …
Article scientifique
Radioguided occult lesion localisation: A retrospective audit at a single tertiary academic breast unit
Background: The radioguided occult lesion localisation (ROLL) technique was introduced at Groote Schuur Hospital in 2003 replacing the wire-guided localisation …
Article scientifique
Long non-coding RNA LINC00470 regulates the growth and epithelial-to-mesenchymal transition of human oral cancer cells
Purpose: To investigate the role of long non-coding RNA LINC00470 in human oral cancer tissues and cell lines (OC3, SCC9 …
Article scientifique
Effects of long non-coding RNA MALAT1-targeting miR-570-3p and miR-34a on the invasion, proliferation, and apoptosis of human retinoblastoma cells
Purpose: To investigate the expression of lncRNA MALAT1-targeting miR-570-3p and miR-34a and its effects on the invasion, proliferation, and apoptosis …
Article scientifique
Synthesis and Study of Anti Fungal Activity of 1,4-benzothiazines Derivatives
Abstract Imines forms an important class of heterocyclic compounds such as1,4-Benzothiazine and its derivatives which shows wide range of biological …
Article scientifique
Riccardin D, a drug candidate, inhibits gastric cancer progression by targeting RAD54L
Purpose: To investigate the beneficial function of RAD54L in gastric cancer. Methods: Batch correction, metaboanalyst, volcano plot and heatmap were …
Article scientifique
MiR 378a/FSCN1 regulatory axis inhibits tumor stemness and increases the cytotoxicity of chemotherapeutic drugs in colorectal cancer cells
Purpose: To evaluate the effect of miR-378a/FSCN1 axis on tumor stemness and aerobic glycolysis in colorectal cancer cells (CRC). Methods: …
Article scientifique
Is MCC950, an NLRP3 inflammasome inhibitor, a renopreventive: A chronic renal failure adenine model in rats
Abstract Background: Chronic renal failure (CRF) is characterized by a great loss in renal function ending with reduced sodium filtration …
Article scientifique
Can Coenzyme Q10 alleviate the toxic effect of fenofibrate on skeletal muscle?
Abstract Fenofibrate is an antilipidemic drug that increases the activity of the lipoprotein lipase enzyme thus enhancing lipolysis, however, it …
Article scientifique
Effect of probiotics for regulation of inflammatory response in radiation-induced enteritis
Article scientifique
Preliminary investigations into the synthesis of lipase cross-linked enzyme aggregates (CLEA) for hydrolysis of lipid-rich wastewater
Abstract Cross-linked enzyme aggregates (CLEA) from Rhizopus oryzae lipase (RoL) was prepared using ammonium sulphate and glutaraldehyde as the precipitant …